Influencia del polimorfismo rs11549465 de HIF-1α en los niveles de hemoglobina y lactato en pacientes de cirugía cardiovascular

Translated title of the contribution: Influence of HIF-1α rs11549465 polymorphism on hemoglobin and lactate levels in cardiovascular surgery patients

Mariana Burgos, Rodrigo Cabrera

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Perioperative anemia is a common complication of cardiovascular surgery. Patients who present the T allele of the HIF-1α rs11549465 polymorphism may have altered hemoglobin and lactate levels before, during and after surgery, compared to the wild-type allele, due to an increased stability of HIF-1 α caused by this allele. Objective: To describe the frequency of the T allele in patients scheduled for cardiovascular surgery, and its relationship with hemoglobin and lactate levels. Materials and methods: DNA was isolated from 84 cardiovascular surgery patients for genotyping by Sanger sequencing. Demographic and clinical characteristics were collected. Results: The frequency of the T allele was 0.066 (95%CI: 0.037-0.114). No significant differences were observed in preoperative, intraoperative, and postoperative hemoglobin and lactate levels between patients with the T allele and those with the wild-type allele. Conclusion: The frequency of the T allele is lower than expected according to other studies in healthy volunteers. No significant differences were observed in some Asian populations, nor in a group of acute myocardial infarction patients. Apparently, rs11549465 genotyping in cardiovascular surgery patients is not a valid risk stratification method for anemia in this group.

Translated title of the contributionInfluence of HIF-1α rs11549465 polymorphism on hemoglobin and lactate levels in cardiovascular surgery patients
Original languageSpanish
Pages (from-to)253-260
Number of pages8
JournalRevista Facultad de Medicina
Volume65
Issue number2
DOIs
StatePublished - 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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