Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study

César A. Agostinis-Sobrinho, Robinson Ramírez-Vélez, Antonio García-Hermoso, Carla Moreira, Luís Lopes, José Oliveira-Santos, Sandra Abreu, Jorge Mota, Rute Santos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Methods: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. Results: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P <.003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. Conclusion: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.

Original languageEnglish (US)
Pages (from-to)429-435
Number of pages7
JournalPediatric Diabetes
Volume19
Issue number3
DOIs
StatePublished - May 1 2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Agostinis-Sobrinho, C. A., Ramírez-Vélez, R., García-Hermoso, A., Moreira, C., Lopes, L., Oliveira-Santos, J., ... Santos, R. (2018). Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study. Pediatric Diabetes, 19(3), 429-435. https://doi.org/10.1111/pedi.12607
Agostinis-Sobrinho, César A. ; Ramírez-Vélez, Robinson ; García-Hermoso, Antonio ; Moreira, Carla ; Lopes, Luís ; Oliveira-Santos, José ; Abreu, Sandra ; Mota, Jorge ; Santos, Rute. / Low-grade inflammation and muscular fitness on insulin resistance in adolescents : Results from LabMed Physical Activity Study. In: Pediatric Diabetes. 2018 ; Vol. 19, No. 3. pp. 429-435.
@article{552d71b41274430d8cfe5460038858e8,
title = "Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study",
abstract = "Background: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Methods: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. Results: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P <.003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95{\%} confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95{\%} CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. Conclusion: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.",
author = "Agostinis-Sobrinho, {C{\'e}sar A.} and Robinson Ram{\'i}rez-V{\'e}lez and Antonio Garc{\'i}a-Hermoso and Carla Moreira and Lu{\'i}s Lopes and Jos{\'e} Oliveira-Santos and Sandra Abreu and Jorge Mota and Rute Santos",
year = "2018",
month = "5",
day = "1",
doi = "10.1111/pedi.12607",
language = "English (US)",
volume = "19",
pages = "429--435",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",
number = "3",

}

Agostinis-Sobrinho, CA, Ramírez-Vélez, R, García-Hermoso, A, Moreira, C, Lopes, L, Oliveira-Santos, J, Abreu, S, Mota, J & Santos, R 2018, 'Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study', Pediatric Diabetes, vol. 19, no. 3, pp. 429-435. https://doi.org/10.1111/pedi.12607

Low-grade inflammation and muscular fitness on insulin resistance in adolescents : Results from LabMed Physical Activity Study. / Agostinis-Sobrinho, César A.; Ramírez-Vélez, Robinson; García-Hermoso, Antonio; Moreira, Carla; Lopes, Luís; Oliveira-Santos, José; Abreu, Sandra; Mota, Jorge; Santos, Rute.

In: Pediatric Diabetes, Vol. 19, No. 3, 01.05.2018, p. 429-435.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low-grade inflammation and muscular fitness on insulin resistance in adolescents

T2 - Results from LabMed Physical Activity Study

AU - Agostinis-Sobrinho, César A.

AU - Ramírez-Vélez, Robinson

AU - García-Hermoso, Antonio

AU - Moreira, Carla

AU - Lopes, Luís

AU - Oliveira-Santos, José

AU - Abreu, Sandra

AU - Mota, Jorge

AU - Santos, Rute

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Methods: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. Results: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P <.003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. Conclusion: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.

AB - Background: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Methods: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. Results: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P <.003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. Conclusion: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.

UR - http://www.scopus.com/inward/record.url?scp=85045933488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045933488&partnerID=8YFLogxK

U2 - 10.1111/pedi.12607

DO - 10.1111/pedi.12607

M3 - Article

C2 - 29171185

AN - SCOPUS:85045933488

VL - 19

SP - 429

EP - 435

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 3

ER -

Agostinis-Sobrinho CA, Ramírez-Vélez R, García-Hermoso A, Moreira C, Lopes L, Oliveira-Santos J et al. Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study. Pediatric Diabetes. 2018 May 1;19(3):429-435. https://doi.org/10.1111/pedi.12607