Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina; Johanna Forero-Rodríguez; Manuel A. Patarroyo

doi:10.1016/j.meegid.2015.05.001

Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina
, Johanna Forero-Rodríguez
, Manuel A. Patarroyo

Research output: Contribution to Journal › Research Article › peer-review

12 Scopus citations

Abstract

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

Original language	English (US)
Pages (from-to)	182-188
Number of pages	7
Journal	Infection, Genetics and Evolution
Volume	33
DOIs	https://doi.org/10.1016/j.meegid.2015.05.001
State	Published - Jul 1 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

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10.1016/j.meegid.2015.05.001

Cite this

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title = "Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion",

abstract = "Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.",

author = "Diego Garz{\'o}n-Ospina and Johanna Forero-Rodr{\'i}guez and Patarroyo, \{Manuel A.\}",

note = "Funding Information: We would like to thank Jason Garry for translating and revising the manuscript. This work was financed by the “ Colombian Science, Technology and Innovation Department (COLCIENCIAS)” through contract RC \# 0309-2013. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.meegid.2015.05.001",

language = "English (US)",

volume = "33",

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AU - Garzón-Ospina, Diego

AU - Forero-Rodríguez, Johanna

AU - Patarroyo, Manuel A.

N1 - Funding Information: We would like to thank Jason Garry for translating and revising the manuscript. This work was financed by the “ Colombian Science, Technology and Innovation Department (COLCIENCIAS)” through contract RC # 0309-2013. Publisher Copyright: © 2015 Elsevier B.V. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

AB - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

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U2 - 10.1016/j.meegid.2015.05.001

DO - 10.1016/j.meegid.2015.05.001

M3 - Research Article

C2 - 25943417

AN - SCOPUS:84937968357

SN - 1567-1348

VL - 33

SP - 182

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JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Abstract

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