Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina, Johanna Forero-Rodríguez, Manuel A. Patarroyo

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalInfection, Genetics and Evolution
Volume33
DOIs
StatePublished - Jul 1 2015

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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