Infectious aspects and the etiopathogenesis of rheumatoid arthritis

Michal Kasher Meron, Howard Amital, Daniel Shepshelovich, Ori Barzilai, Maya Ram, Juan Manuel Anaya, Roberto Gerli, Bizzaro Nicola, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Infections are believed to contribute to the maturation of the immune system from the innate to the adaptive phases and therefore may take part in the induction of autoimmune conditions. In the current study, we present an extensive analysis conducted on sera samples of patients with rheumatoid arthritis in order to seek evidence of previous or coexisting infectious processes using the Bio-Rad BioPlex immunoassay analyzer. We detected higher rates of serological evidence of infections with Epstein-Barr virus and cytomegalovirus viruses. Our findings may indicate a role of these viruses in the pathogenesis of RA.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalClinical Reviews in Allergy and Immunology
Volume38
Issue number2-3
DOIs
StatePublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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