Infectious aspects and the etiopathogenesis of rheumatoid arthritis

Michal Kasher Meron; Howard Amital; Daniel Shepshelovich; Ori Barzilai; Maya Ram; Juan Manuel Anaya; Roberto Gerli; Bizzaro Nicola; Yehuda Shoenfeld

doi:10.1007/s12016-009-8158-6

Infectious aspects and the etiopathogenesis of rheumatoid arthritis

Michal Kasher Meron, Howard Amital, Daniel Shepshelovich, Ori Barzilai, Maya Ram, Juan Manuel Anaya, Roberto Gerli, Bizzaro Nicola, Yehuda Shoenfeld

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45 Scopus citations

Abstract

Infections are believed to contribute to the maturation of the immune system from the innate to the adaptive phases and therefore may take part in the induction of autoimmune conditions. In the current study, we present an extensive analysis conducted on sera samples of patients with rheumatoid arthritis in order to seek evidence of previous or coexisting infectious processes using the Bio-Rad BioPlex immunoassay analyzer. We detected higher rates of serological evidence of infections with Epstein-Barr virus and cytomegalovirus viruses. Our findings may indicate a role of these viruses in the pathogenesis of RA.

Original language	English (US)
Pages (from-to)	287-291
Number of pages	5
Journal	Clinical Reviews in Allergy and Immunology
Volume	38
Issue number	2-3
DOIs	https://doi.org/10.1007/s12016-009-8158-6
State	Published - Apr 2010

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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10.1007/s12016-009-8158-6

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abstract = "Infections are believed to contribute to the maturation of the immune system from the innate to the adaptive phases and therefore may take part in the induction of autoimmune conditions. In the current study, we present an extensive analysis conducted on sera samples of patients with rheumatoid arthritis in order to seek evidence of previous or coexisting infectious processes using the Bio-Rad BioPlex immunoassay analyzer. We detected higher rates of serological evidence of infections with Epstein-Barr virus and cytomegalovirus viruses. Our findings may indicate a role of these viruses in the pathogenesis of RA.",

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AU - Meron, Michal Kasher

AU - Amital, Howard

AU - Shepshelovich, Daniel

AU - Barzilai, Ori

AU - Ram, Maya

AU - Anaya, Juan Manuel

AU - Gerli, Roberto

AU - Nicola, Bizzaro

AU - Shoenfeld, Yehuda

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AB - Infections are believed to contribute to the maturation of the immune system from the innate to the adaptive phases and therefore may take part in the induction of autoimmune conditions. In the current study, we present an extensive analysis conducted on sera samples of patients with rheumatoid arthritis in order to seek evidence of previous or coexisting infectious processes using the Bio-Rad BioPlex immunoassay analyzer. We detected higher rates of serological evidence of infections with Epstein-Barr virus and cytomegalovirus viruses. Our findings may indicate a role of these viruses in the pathogenesis of RA.

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Infectious aspects and the etiopathogenesis of rheumatoid arthritis

Abstract

All Science Journal Classification (ASJC) codes

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