Programación Fetal in utero y su impacto en la salud del adulto

Translated title of the contribution: In Utero Fetal Programming and Its Impact on Health in Adulthood

Robinson Ramírez-Vélez

Research output: Contribution to journalShort surveypeer-review

27 Scopus citations


Adverse events during intrauterine life may program organ growth and favor disease later in life. This is the usually called 'Barker's hypothesis'. Increasing evidence suggests that conditions like vascular disease, hypertension, metabolic syndrome, and type 2 diabetes mellitus are programmed during the early stages of fetal development and become manifest in late stages of life, when there is an added impact of lifestyle and other conventional acquired environmental risk factors that interact with genetic factors. The aim of this review was to provide additional, updated evidence to support the association between intrauterine fetal health and increased prevalence of chronic non-communicable diseases in adulthood. Various potential cellular and molecular mechanisms proposed to be related to the above hypothesis are discussed, including endothelial function, oxidative stress, insulin resistance, and mitochondrial function.

Translated title of the contributionIn Utero Fetal Programming and Its Impact on Health in Adulthood
Original languageEstonian
Pages (from-to)383-393
Number of pages11
JournalEndocrinologia y Nutricion
Issue number6
StatePublished - Jun 1 2012

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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