Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide.

B cells play a key role in regulating the immune system by producing antibodies, acting as antigen-presenting cells, providing support to other mononuclear cells, and contributing directly to inflammatory pathways. Accumulating evidence indicates that there is a disruption of these regulated processes in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). In RA there is a chronic inflammation in the affected joints leading to the development of ectopic germinal centers. A micro-environment is established which supports B cell activation and differentiation. Plasma cells may develop which secrete autoantibodies of high affinity directly into the synovial tissue. As a result, antigen/antibody complex formation, the activation of the complement cascade and the stimulation of macrophages may contribute to the destruction of joints. B cells also play a pivotal role in the activation of synovial T cells and the induction of cytokine secretion. Finally, the success of B cell depletion therapy by using monoclonal antibodies against CD20 further emphasized the importance of B cells in the pathogenesis of RA (English) [ABSTRACT FROM AUTHOR]