Impaired cerebral autoregulation using near-infrared spectroscopy and its relation to clinical outcomes in premature infants

Alexander Caicedo, Dominique De Smet, Joke Vanderhaegen, Gunnar Naulaers, Martin Wolf, Petra Lemmers, Frank Van Bel, Lieveke Ameye, Sabine Van Huffel

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23 Scopus citations


The concordance between the change in the Mean Arterial Blood Pressure (MABP) and the Cerebral Blood Flow (CBF) is studied using the Correlation, Coherence and Partial Coherence methods in order to detect Impaired Cerebral Autoregulation in Neonates. The presence of impaired autoregulation is assessed by the use of the Critical Percentage of Recording Time (CPRT). The changes in CBF are reflected by the measurement of changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO2), and cerebral tissue oxygenation (TOI), as measured by Near-Infrared Spectroscopy (NIRS) (INVOS4100 and NIRO300). The relation between impaired autoregulation and long term clinical outcomes in premature infants is studied.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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