Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders

Jurgen Sota, Silvana Guerriero, Giuseppe Lopalco, Abdurrahman Tufan, Gaafar Ragab, Ibrahim AlMaglouth, Marcello Govoni, Petros P. Sfikakis, Micol Frassi, Antonio Vitale, Riza Can Kardas, Paola Triaggianese, Maria Sole Chimenti, Aos A. Aboabat, Matteo Piga, Sara Monti, Gian Domenico Sebastiani, Derya Yildirim, Alessandro Conforti, Stefano GentileschiRosanna Dammacco, Andrea Hinojosa-Azaola, Perla Ayumi Kawakami-Campos, Francesca Ruffilli, Jiram Torres-Ruiz, Maissa Thabet, Amira Atig, Piero Ruscitti, Giulia Cataldi, Ombretta Viapiana, Gülen Hatemi, Alican Karakoç, Stefania Costi, Annamaria Iagnocco, Francesca Crisafulli, George Fragoulis, Emanuela Del Giudice, Mohamed Tharwat Hegazy, Maria Pia Paroli, Ali Şahin, Maria Morrone, Florenzo Iannone, Daniela Opris-Belinski, Kazi Nur Asfina, Patrizia Barone, Carla Gaggiano, Hamit Kucuk, Maria Francesca Gicchino, Francesco Carubbi, Valeria Caggiano, Katerina Laskari, Samar Tharwat, Haner Direskeneli, Fatma Alibaz-Oner, Gizem Sevik, Armin Maier, Ahmed Hatem Laymouna, Giacomo Emmi, Nurullah Akkoç, Maria Tarsia, Jessica Sbalchiero, Giovanni Conti, Rosaria Spinella, Francesco La Torre, Enrico Tombetti, Rana Hussein Amin, Angela Mauro, Anastasios Karamanakos, Ester Carreño, Alex Fonollosa, Marco Cattalini, Luciana Breda, Alejandra de-la-Torre, Ewa Wiesik-Szewczyk, Carlos Cifuentes-González, Seza Ozen, Maria Antonietta Mazzei, Gian Marco Tosi, Bruno Frediani, Alberto Balistreri, Ezgi Deniz Batu, Vishali Gupta, Luca Cantarini, Claudia Fabiani

Research output: Contribution to journalResearch Articlepeer-review

Abstract

Purpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown. Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time. Results: Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99). Conclusions: Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.

Translated title of the contributionImpacto del HLA-B51 en la uveítis y la vasculitis retiniana: Datos de los Registros de la Red Internacional AIDA sobre Trastornos Inflamatorios Oculares
Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StatePublished - May 17 2024

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

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