TY - JOUR
T1 - Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations
AU - Juan Manuel Anaya
AU - Sánchez, Elena
AU - Rasmussen, Astrid
AU - Riba, Laura
AU - Acevedo-Vasquez, Eduardo
AU - Kelly, Jennifer A.
AU - Langefeld, Carl D.
AU - Williams, Adrianne H.
AU - Ziegler, Julie T.
AU - Comeau, Mary E.
AU - Marion, Miranda C.
AU - García-De La Torre, Ignacio
AU - Maradiaga-Ceceña, Marco A.
AU - Cardiel, Mario H.
AU - Esquivel-Valerio, Jorge A.
AU - Rodriguez-Amado, Jacqueline
AU - Moctezuma, José Francisco
AU - Miranda, Pedro
AU - Perandones, Carlos E.
AU - Castel, Cecilia
AU - Laborde, Hugo A.
AU - Alba, Paula
AU - Musuruana, Jorge L.
AU - Goecke, I. Annelise
AU - Anaya, Juan Manuel
AU - Kaufman, Kenneth M.
AU - Adler, Adam
AU - Glenn, Stuart B.
AU - Brown, Elizabeth E.
AU - Alarcón, Graciela S.
AU - Kimberly, Robert P.
AU - Edberg, Jeffrey C.
AU - Vilá, Luis M.
AU - Criswell, Lindsey A.
AU - Gilkeson, Gary S.
AU - Niewold, Timothy B.
AU - Martín, Javier
AU - Vyse, Timothy J.
AU - Boackle, Susan A.
AU - Ramsey-Goldman, Rosalind
AU - Scofield, R. Hal
AU - Petri, Michelle
AU - Merrill, Joan T.
AU - Reveille, John D.
AU - Tsao, Betty P.
AU - Orozco, Lorena
AU - Baca, Vicente
AU - Moser, Kathy L.
AU - Gaffney, Patrick M.
AU - James, Judith A.
AU - Harley, John B.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/11
Y1 - 2012/11
N2 - Objective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients. Methods A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement (P < 0.0001, OR 3.50 [95% CI 2.63- 4.63]) and early age at onset (P < 0.0001). American Indian ancestry protected against photosensitivity (P < 0.0001, OR 0.58 [95% CI 0.44-0.76]), oral ulcers (P < 0.0001, OR 0.55 [95% CI 0.42-0.72]), and serositis (P < 0.0001, OR 0.56 [95% CI 0.41-0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement. Conclusion In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age.
AB - Objective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients. Methods A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement (P < 0.0001, OR 3.50 [95% CI 2.63- 4.63]) and early age at onset (P < 0.0001). American Indian ancestry protected against photosensitivity (P < 0.0001, OR 0.58 [95% CI 0.44-0.76]), oral ulcers (P < 0.0001, OR 0.55 [95% CI 0.42-0.72]), and serositis (P < 0.0001, OR 0.56 [95% CI 0.41-0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement. Conclusion In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age.
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U2 - 10.1002/art.34650
DO - 10.1002/art.34650
M3 - Research Article
C2 - 22886787
AN - SCOPUS:84868092719
SN - 0004-3591
VL - 64
SP - 3687
EP - 3694
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 11
ER -