Immune protection-inducing protein structures (IMPIPS) against malaria: The weapons needed for beating Odysseus

Manuel E. Patarroyo; Manuel A. Patarroyo; Laura Pabón; Hernando Curtidor; Luis A. Poloche

doi:10.1016/j.vaccine.2015.09.109

Immune protection-inducing protein structures (IMPIPS) against malaria: The weapons needed for beating Odysseus

Manuel E. Patarroyo, Manuel A. Patarroyo, Laura Pabón, Hernando Curtidor, Luis A. Poloche

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.

Original language	English (US)
Pages (from-to)	7525-7537
Number of pages	13
Journal	Vaccine
Volume	33
Issue number	52
DOIs	https://doi.org/10.1016/j.vaccine.2015.09.109
State	Published - Dec 22 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2015.09.109

Cite this

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abstract = "The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.",

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AU - Curtidor, Hernando

AU - Poloche, Luis A.

N1 - Funding Information: We would like to thank Jason Garry for translating this manuscript. This research has been supported by the Colombian Science, Technology and Innovation Department (COLCIENCIAS) through contract RC # 0309-2013. Publisher Copyright: © 2015 Elsevier Ltd. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.

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Immune protection-inducing protein structures (IMPIPS) against malaria: The weapons needed for beating Odysseus

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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