Immune protection-inducing protein structures (IMPIPS) against malaria: The weapons needed for beating Odysseus

Manuel E. Patarroyo, Manuel A. Patarroyo, Laura Pabón, Hernando Curtidor, Luis A. Poloche

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.

Original languageEnglish (US)
Pages (from-to)7525-7537
Number of pages13
JournalVaccine
Volume33
Issue number52
DOIs
StatePublished - Dec 22 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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