Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)

Hernando Curtidor; Liliana C. Patiño; Gabriela Arévalo-Pinzón; Manuel E. Patarroyo; Manuel A. Patarroyo

doi:10.1016/j.gene.2010.12.005

Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)

Hernando Curtidor, Liliana C. Patiño, Gabriela Arévalo-Pinzón, Manuel E. Patarroyo, Manuel A. Patarroyo

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Abstract

Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease. Many of these proteins have been studied in Toxoplasma gondii, where some belonging to the Moving Junction complex have been identified. This complex allows a strong interaction between host cell and parasite membranes, required for parasite invasion. In this genus, four rhoptry proteins (RON2, RON4, RON5 and RON8) and one micronemal protein (TgAMA-1) have been found as part of the complex. In Plasmodium falciparum, RON2 and RON4 have been characterized. In the present study, we identify PfRON5, a ~. 110. kDa protein which is expressed in merozoite and schizont stages of the FCB-2 strain.

Original language	English (US)
Pages (from-to)	22-28
Number of pages	7
Journal	Gene
Volume	474
Issue number	1-2
DOIs	https://doi.org/10.1016/j.gene.2010.12.005
State	Published - Mar 15 2011

All Science Journal Classification (ASJC) codes

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.gene.2010.12.005

Cite this

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title = "Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)",

abstract = "Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease. Many of these proteins have been studied in Toxoplasma gondii, where some belonging to the Moving Junction complex have been identified. This complex allows a strong interaction between host cell and parasite membranes, required for parasite invasion. In this genus, four rhoptry proteins (RON2, RON4, RON5 and RON8) and one micronemal protein (TgAMA-1) have been found as part of the complex. In Plasmodium falciparum, RON2 and RON4 have been characterized. In the present study, we identify PfRON5, a ~. 110. kDa protein which is expressed in merozoite and schizont stages of the FCB-2 strain.",

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T1 - Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)

AU - Curtidor, Hernando

AU - Patiño, Liliana C.

AU - Arévalo-Pinzón, Gabriela

AU - Patarroyo, Manuel E.

AU - Patarroyo, Manuel A.

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease. Many of these proteins have been studied in Toxoplasma gondii, where some belonging to the Moving Junction complex have been identified. This complex allows a strong interaction between host cell and parasite membranes, required for parasite invasion. In this genus, four rhoptry proteins (RON2, RON4, RON5 and RON8) and one micronemal protein (TgAMA-1) have been found as part of the complex. In Plasmodium falciparum, RON2 and RON4 have been characterized. In the present study, we identify PfRON5, a ~. 110. kDa protein which is expressed in merozoite and schizont stages of the FCB-2 strain.

AB - Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease. Many of these proteins have been studied in Toxoplasma gondii, where some belonging to the Moving Junction complex have been identified. This complex allows a strong interaction between host cell and parasite membranes, required for parasite invasion. In this genus, four rhoptry proteins (RON2, RON4, RON5 and RON8) and one micronemal protein (TgAMA-1) have been found as part of the complex. In Plasmodium falciparum, RON2 and RON4 have been characterized. In the present study, we identify PfRON5, a ~. 110. kDa protein which is expressed in merozoite and schizont stages of the FCB-2 strain.

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Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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