Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

E. C. Hernández; C. F. Suárez; C. A. Parra; M. A. Patarroyo; Manuel E. Patarroyo

doi:10.1111/j.1399-0039.2005.00491.x

Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

E. C. Hernández
, C. F. Suárez
, C. A. Parra
, M. A. Patarroyo
, Manuel E. Patarroyo

Research output: Contribution to Journal › Research Article › peer-review

7 Scopus citations

Abstract

In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. © 2005 Blackwell Munksgaard.

Translated title of the contribution	Identificación de cinco familias diferentes de genes IGHV en monos búho (Aotus nancymaae)
Original language	English (US)
Pages (from-to)	640-649
Number of pages	10
Journal	Tissue Antigens
Volume	66
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0039.2005.00491.x
State	Published - Dec 1 2005

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology

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10.1111/j.1399-0039.2005.00491.x

Cite this

@article{630a00108c804a95a6c1fa81fd02cb19,

title = "Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)",

abstract = "In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91\% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. {\textcopyright} 2005 Blackwell Munksgaard.",

author = "Hern{\'a}ndez, \{E. C.\} and Su{\'a}rez, \{C. F.\} and Parra, \{C. A.\} and Patarroyo, \{M. A.\} and Patarroyo, \{Manuel E.\}",

year = "2005",

month = dec,

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doi = "10.1111/j.1399-0039.2005.00491.x",

language = "English (US)",

volume = "66",

pages = "640--649",

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}

TY - JOUR

T1 - Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

AU - Hernández, E. C.

AU - Suárez, C. F.

AU - Parra, C. A.

AU - Patarroyo, M. A.

AU - Patarroyo, Manuel E.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. © 2005 Blackwell Munksgaard.

AB - In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. © 2005 Blackwell Munksgaard.

U2 - 10.1111/j.1399-0039.2005.00491.x

DO - 10.1111/j.1399-0039.2005.00491.x

M3 - Research Article

C2 - 16305680

SN - 0001-2815

VL - 66

SP - 640

EP - 649

JO - Tissue Antigens

JF - Tissue Antigens

IS - 6

ER -

Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

Abstract

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All Science Journal Classification (ASJC) codes

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