Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis

Rafael Parra-Medina, Liliana López-Kleine, Sandra Ramírez-Clavijo, César Payán-Gómez

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identified as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identified miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets.

Translated title of the contributionIdentificación de miRNAs en cáncer de próstata temprano y tardío mediante el análisis de redes de coexpresion
Original languageEnglish (US)
Article number12345
Pages (from-to)1-15
Number of pages15
JournalScientific Reports
Volume10
Issue number1
DOIs
StatePublished - Jul 23 2020

All Science Journal Classification (ASJC) codes

  • General

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