Human polymorphism at microRNAs and microRNA target sites.

Liuqing Yang, Chunru Lin, Chunyu Jin, Joy C. Yang, Bogdan Tanasa, Wenbo Wen-Hsiung Li, Daria Merkurjev, Kenneth a. Ohgi, Jie Zhang, Christopher P. Evans, Michael G. Rosenfeld, Charles E Vejnar, Matthias Blum, Evgeny M Zdobnov, A Turchinovich, T R Samatov, a G Tonevitsky, B Burwinkel, Georg Schett, Dirk ElewautIain B McInnes, Jean-Michel Dayer, Markus F Neurath, Sachin Pundhir, Jan Gorodkin, Fabiola Olivieri, Maria R Rippo, Antonio D Procopio, Francesca Fazioli, Lukas T Jeker, Xuyu Zhou, Robert Blelloch, Jeffrey a Bluestone, Claudiane Guay, Romano Regazzi, Roopali Gandhi, Brian Healy, Taha Gholipour, Svetlana Egorova, Alexander Musallam, Mohammad Shuja Hussain, Parham Nejad, Bonny Patel, Hillary Hei, Samia Khoury, Francisco Quintana, Pia Kivisakk, Tanuja Chitnis, Howard L Weiner, Yun Deng, Jian Zhao, Daisuke Sakurai, Kenneth M. Kaufman, Jeffrey C. Edberg, Robert P. Kimberly, Diane L. Kamen, Gary S. Gilkeson, Chaim O. Jacob, R. Hal Scofield, Carl D. Langefeld, Jennifer A. Kelly, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vilá, Graciela S. Alarcón, Timothy J. Vyse, Bernardo A Pons-Estel, Barry I. Freedman, Patrick M. Gaffney, Kathy Moser Sivils, Judith A. James, Peter K Gregersen, Juan-Manuel Anaya, Timothy B. Niewold, Joan T. Merrill, Lindsey A. Criswell, Anne M. Stevens, Susan A. Boackle, Rita M. Cantor, Weiling Chen, Jeniffer M Grossman, Bevra H. Hahn, John B. Harley, Marta E Alarcόn-Riquelme, Elizabeth E. Brown, Betty P. Tsao, Susan Carpenter, Maninjay Atianand, Daniel Aiello, Emiliano P Ricci, Pallavi Gandhi, Lisa L Hall, Meg Byron, Brian Monks, Meabh Henry-Bezy, Jeanne B Lawrence, Luke a J O'Neill, Melissa J Moore, Daniel R Caffrey, Katherine a Fitzgerald, Dan-Xia Zhu, Lei Fan, Rui-Nan Lu, Cheng Fang, Wen-Yi Shen, Zhi-Jian Zou, Yin-Hua Wang, Hua-Yuan Zhu, Kou-Rong Miao, Peng Liu, Wei Xu, Jian-Yong Li, Jing Gong, Yin Tong, Hong-Mei Zhang, Kai Wang, Tao Hu, Ge Shan, Jun Sun, An-Yuan Guo, V Davalos, C Moutinho, A Villanueva, R Boque, Pedro Silva, F Carneiro, M Esteller, R Stephanie Huang, Eric R Gamazon, Dana Ziliak, Yujia Wen, Hae Kyung Im, Wei Zhang, Claudia Wing, Shiwei Duan, Wasim K Bleibel, Nancy J Cox, M Eileen Dolan, Patrick Brest, Pierre Lapaquette, Mouloud Souidi, Kevin Lebrigand, Annabelle Cesaro, Valérie Vouret-Craviari, Bernard Mari, Pascal Barbry, Jean-François Mosnier, Xavier Hébuterne, Annick Harel-Bellan, Baharia Mograbi, Arlette Darfeuille-Michaud, Paul Hofman, Jonathan Marchini, Bryan Howie, Lucia a Hindorff, Praveen Sethupathy, Heather a Junkins, Erin M Ramos, Jayashri P Mehta, Francis S Collins, Teri a Manolio, William Cookson, Liming Liang, Gonçalo R. Abecasis, Miriam Moffatt, Mark Lathrop, Matthew a Saunders, Han Liang

Research output: Contribution to journalArticlepeer-review

265 Scopus citations

Abstract

Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.
Original languageEnglish (US)
Pages (from-to)2062-74
Number of pages13
JournalFrontiers in Genetics
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2013

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