Abstract
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2062-74 |
| Number of pages | 13 |
| Journal | Frontiers in Genetics |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2013 |
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Human polymorphism at microRNAs and microRNA target sites. / Yang, Liuqing; Lin, Chunru; Jin, Chunyu; Yang, Joy C.; Tanasa, Bogdan; Li, Wenbo Wen-Hsiung; Merkurjev, Daria; Ohgi, Kenneth a.; Zhang, Jie; Evans, Christopher P.; Rosenfeld, Michael G.; Vejnar, Charles E; Blum, Matthias; Zdobnov, Evgeny M; Turchinovich, A; Samatov, T R; Tonevitsky, a G; Burwinkel, B; Schett, Georg; Elewaut, Dirk; McInnes, Iain B; Dayer, Jean-Michel; Neurath, Markus F; Pundhir, Sachin; Gorodkin, Jan; Olivieri, Fabiola; Rippo, Maria R; Procopio, Antonio D; Fazioli, Francesca; Jeker, Lukas T; Zhou, Xuyu; Blelloch, Robert; Bluestone, Jeffrey a; Guay, Claudiane; Regazzi, Romano; Gandhi, Roopali; Healy, Brian; Gholipour, Taha; Egorova, Svetlana; Musallam, Alexander; Hussain, Mohammad Shuja; Nejad, Parham; Patel, Bonny; Hei, Hillary; Khoury, Samia; Quintana, Francisco; Kivisakk, Pia; Chitnis, Tanuja; Weiner, Howard L; Deng, Yun; Zhao, Jian; Sakurai, Daisuke; Kaufman, Kenneth M.; Edberg, Jeffrey C.; Kimberly, Robert P.; Kamen, Diane L.; Gilkeson, Gary S.; Jacob, Chaim O.; Scofield, R. Hal; Langefeld, Carl D.; Kelly, Jennifer A.; Ramsey-Goldman, Rosalind; Petri, Michelle A.; Reveille, John D.; Vilá, Luis M.; Alarcón, Graciela S.; Vyse, Timothy J.; Pons-Estel, Bernardo A; Freedman, Barry I.; Gaffney, Patrick M.; Sivils, Kathy Moser; James, Judith A.; Gregersen, Peter K; Anaya, Juan-Manuel; Niewold, Timothy B.; Merrill, Joan T.; Criswell, Lindsey A.; Stevens, Anne M.; Boackle, Susan A.; Cantor, Rita M.; Chen, Weiling; Grossman, Jeniffer M; Hahn, Bevra H.; Harley, John B.; Alarcόn-Riquelme, Marta E; Brown, Elizabeth E.; Tsao, Betty P.; Carpenter, Susan; Atianand, Maninjay; Aiello, Daniel; Ricci, Emiliano P; Gandhi, Pallavi; Hall, Lisa L; Byron, Meg; Monks, Brian; Henry-Bezy, Meabh; Lawrence, Jeanne B; O'Neill, Luke a J; Moore, Melissa J; Caffrey, Daniel R; Fitzgerald, Katherine a; Zhu, Dan-Xia; Fan, Lei; Lu, Rui-Nan; Fang, Cheng; Shen, Wen-Yi; Zou, Zhi-Jian; Wang, Yin-Hua; Zhu, Hua-Yuan; Miao, Kou-Rong; Liu, Peng; Xu, Wei; Li, Jian-Yong; Gong, Jing; Tong, Yin; Zhang, Hong-Mei; Wang, Kai; Hu, Tao; Shan, Ge; Sun, Jun; Guo, An-Yuan; Davalos, V; Moutinho, C; Villanueva, A; Boque, R; Silva, Pedro; Carneiro, F; Esteller, M; Huang, R Stephanie; Gamazon, Eric R; Ziliak, Dana; Wen, Yujia; Im, Hae Kyung; Zhang, Wei; Wing, Claudia; Duan, Shiwei; Bleibel, Wasim K; Cox, Nancy J; Dolan, M Eileen; Brest, Patrick; Lapaquette, Pierre; Souidi, Mouloud; Lebrigand, Kevin; Cesaro, Annabelle; Vouret-Craviari, Valérie; Mari, Bernard; Barbry, Pascal; Mosnier, Jean-François; Hébuterne, Xavier; Harel-Bellan, Annick; Mograbi, Baharia; Darfeuille-Michaud, Arlette; Hofman, Paul; Marchini, Jonathan; Howie, Bryan; Hindorff, Lucia a; Sethupathy, Praveen; Junkins, Heather a; Ramos, Erin M; Mehta, Jayashri P; Collins, Francis S; Manolio, Teri a; Cookson, William; Liang, Liming; Abecasis, Gonçalo R.; Moffatt, Miriam; Lathrop, Mark; Saunders, Matthew a; Liang, Han.
In: Frontiers in Genetics, Vol. 4, No. 3, 01.01.2013, p. 2062-74.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Human polymorphism at microRNAs and microRNA target sites.
AU - Yang, Liuqing
AU - Lin, Chunru
AU - Jin, Chunyu
AU - Yang, Joy C.
AU - Tanasa, Bogdan
AU - Li, Wenbo Wen-Hsiung
AU - Merkurjev, Daria
AU - Ohgi, Kenneth a.
AU - Zhang, Jie
AU - Evans, Christopher P.
AU - Rosenfeld, Michael G.
AU - Vejnar, Charles E
AU - Blum, Matthias
AU - Zdobnov, Evgeny M
AU - Turchinovich, A
AU - Samatov, T R
AU - Tonevitsky, a G
AU - Burwinkel, B
AU - Schett, Georg
AU - Elewaut, Dirk
AU - McInnes, Iain B
AU - Dayer, Jean-Michel
AU - Neurath, Markus F
AU - Pundhir, Sachin
AU - Gorodkin, Jan
AU - Olivieri, Fabiola
AU - Rippo, Maria R
AU - Procopio, Antonio D
AU - Fazioli, Francesca
AU - Jeker, Lukas T
AU - Zhou, Xuyu
AU - Blelloch, Robert
AU - Bluestone, Jeffrey a
AU - Guay, Claudiane
AU - Regazzi, Romano
AU - Gandhi, Roopali
AU - Healy, Brian
AU - Gholipour, Taha
AU - Egorova, Svetlana
AU - Musallam, Alexander
AU - Hussain, Mohammad Shuja
AU - Nejad, Parham
AU - Patel, Bonny
AU - Hei, Hillary
AU - Khoury, Samia
AU - Quintana, Francisco
AU - Kivisakk, Pia
AU - Chitnis, Tanuja
AU - Weiner, Howard L
AU - Deng, Yun
AU - Zhao, Jian
AU - Sakurai, Daisuke
AU - Kaufman, Kenneth M.
AU - Edberg, Jeffrey C.
AU - Kimberly, Robert P.
AU - Kamen, Diane L.
AU - Gilkeson, Gary S.
AU - Jacob, Chaim O.
AU - Scofield, R. Hal
AU - Langefeld, Carl D.
AU - Kelly, Jennifer A.
AU - Ramsey-Goldman, Rosalind
AU - Petri, Michelle A.
AU - Reveille, John D.
AU - Vilá, Luis M.
AU - Alarcón, Graciela S.
AU - Vyse, Timothy J.
AU - Pons-Estel, Bernardo A
AU - Freedman, Barry I.
AU - Gaffney, Patrick M.
AU - Sivils, Kathy Moser
AU - James, Judith A.
AU - Gregersen, Peter K
AU - Anaya, Juan-Manuel
AU - Niewold, Timothy B.
AU - Merrill, Joan T.
AU - Criswell, Lindsey A.
AU - Stevens, Anne M.
AU - Boackle, Susan A.
AU - Cantor, Rita M.
AU - Chen, Weiling
AU - Grossman, Jeniffer M
AU - Hahn, Bevra H.
AU - Harley, John B.
AU - Alarcόn-Riquelme, Marta E
AU - Brown, Elizabeth E.
AU - Tsao, Betty P.
AU - Carpenter, Susan
AU - Atianand, Maninjay
AU - Aiello, Daniel
AU - Ricci, Emiliano P
AU - Gandhi, Pallavi
AU - Hall, Lisa L
AU - Byron, Meg
AU - Monks, Brian
AU - Henry-Bezy, Meabh
AU - Lawrence, Jeanne B
AU - O'Neill, Luke a J
AU - Moore, Melissa J
AU - Caffrey, Daniel R
AU - Fitzgerald, Katherine a
AU - Zhu, Dan-Xia
AU - Fan, Lei
AU - Lu, Rui-Nan
AU - Fang, Cheng
AU - Shen, Wen-Yi
AU - Zou, Zhi-Jian
AU - Wang, Yin-Hua
AU - Zhu, Hua-Yuan
AU - Miao, Kou-Rong
AU - Liu, Peng
AU - Xu, Wei
AU - Li, Jian-Yong
AU - Gong, Jing
AU - Tong, Yin
AU - Zhang, Hong-Mei
AU - Wang, Kai
AU - Hu, Tao
AU - Shan, Ge
AU - Sun, Jun
AU - Guo, An-Yuan
AU - Davalos, V
AU - Moutinho, C
AU - Villanueva, A
AU - Boque, R
AU - Silva, Pedro
AU - Carneiro, F
AU - Esteller, M
AU - Huang, R Stephanie
AU - Gamazon, Eric R
AU - Ziliak, Dana
AU - Wen, Yujia
AU - Im, Hae Kyung
AU - Zhang, Wei
AU - Wing, Claudia
AU - Duan, Shiwei
AU - Bleibel, Wasim K
AU - Cox, Nancy J
AU - Dolan, M Eileen
AU - Brest, Patrick
AU - Lapaquette, Pierre
AU - Souidi, Mouloud
AU - Lebrigand, Kevin
AU - Cesaro, Annabelle
AU - Vouret-Craviari, Valérie
AU - Mari, Bernard
AU - Barbry, Pascal
AU - Mosnier, Jean-François
AU - Hébuterne, Xavier
AU - Harel-Bellan, Annick
AU - Mograbi, Baharia
AU - Darfeuille-Michaud, Arlette
AU - Hofman, Paul
AU - Marchini, Jonathan
AU - Howie, Bryan
AU - Hindorff, Lucia a
AU - Sethupathy, Praveen
AU - Junkins, Heather a
AU - Ramos, Erin M
AU - Mehta, Jayashri P
AU - Collins, Francis S
AU - Manolio, Teri a
AU - Cookson, William
AU - Liang, Liming
AU - Abecasis, Gonçalo R.
AU - Moffatt, Miriam
AU - Lathrop, Mark
AU - Saunders, Matthew a
AU - Liang, Han
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.
AB - Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.
U2 - 10.1038/ng.940
DO - 10.1038/ng.940
M3 - Article
C2 - 22045659
VL - 4
SP - 2062
EP - 2074
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
IS - 3
ER -