How not to search for isochores: A reply to Cohen et al

Oliver Clay, Giorgio Bernardi

Research output: Contribution to journalResearch Articlepeer-review

15 Scopus citations


In a recent paper in these pages, Cohen et al. search for isochores in the human genome, based on a system of attributes that they assign to isochores. The putative isochores that they find and choose for presentation are almost all below 45% GC and cover only about 41% of the genome. Closer inspection reveals that the authors' methodology systematically loses GC-rich isochores because it does not anticipate the considerable fluctuations and corresponding long-range correlations that characterize mammalian DNA and that are highest in GC-rich DNA. Thus, they over-fragment GC-rich isochores (and also many GC-poor isochores) beyond recognition.

Original languageEnglish (US)
Pages (from-to)2315-2317
Number of pages3
JournalMolecular Biology and Evolution
Issue number12
StatePublished - Dec 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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