Abstract
In a recent paper in these pages, Cohen et al. search for isochores in the human genome, based on a system of attributes that they assign to isochores. The putative isochores that they find and choose for presentation are almost all below 45% GC and cover only about 41% of the genome. Closer inspection reveals that the authors' methodology systematically loses GC-rich isochores because it does not anticipate the considerable fluctuations and corresponding long-range correlations that characterize mammalian DNA and that are highest in GC-rich DNA. Thus, they over-fragment GC-rich isochores (and also many GC-poor isochores) beyond recognition.
Original language | English (US) |
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Pages (from-to) | 2315-2317 |
Number of pages | 3 |
Journal | Molecular Biology and Evolution |
Volume | 22 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics