HLA-DRB1 the notorious gene in the mosaic of autoimmunity

María Teresa Arango, Carlo Perricone, Shaye Kivity, Enrica Cipriano, Fulvia Ceccarelli, Guido Valesini, Yehuda Shoenfeld

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition.

Original languageEnglish (US)
Pages (from-to)82-98
Number of pages17
JournalImmunologic Research
Volume65
Issue number1
DOIs
StatePublished - Feb 1 2017

Fingerprint

HLA Antigens
Autoimmunity
Genes
Autoimmune Diseases
Precision Medicine
Antigen Presentation
Multigene Family
Major Histocompatibility Complex
Mammals
Vaccines
Genome
Antigens
Infection
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Arango, M. T., Perricone, C., Kivity, S., Cipriano, E., Ceccarelli, F., Valesini, G., & Shoenfeld, Y. (2017). HLA-DRB1 the notorious gene in the mosaic of autoimmunity. Immunologic Research, 65(1), 82-98. https://doi.org/10.1007/s12026-016-8817-7
Arango, María Teresa ; Perricone, Carlo ; Kivity, Shaye ; Cipriano, Enrica ; Ceccarelli, Fulvia ; Valesini, Guido ; Shoenfeld, Yehuda. / HLA-DRB1 the notorious gene in the mosaic of autoimmunity. In: Immunologic Research. 2017 ; Vol. 65, No. 1. pp. 82-98.
@article{6aaafe08f7104c73847e474bd3a10462,
title = "HLA-DRB1 the notorious gene in the mosaic of autoimmunity",
abstract = "The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition.",
author = "Arango, {Mar{\'i}a Teresa} and Carlo Perricone and Shaye Kivity and Enrica Cipriano and Fulvia Ceccarelli and Guido Valesini and Yehuda Shoenfeld",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s12026-016-8817-7",
language = "English (US)",
volume = "65",
pages = "82--98",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "1",

}

Arango, MT, Perricone, C, Kivity, S, Cipriano, E, Ceccarelli, F, Valesini, G & Shoenfeld, Y 2017, 'HLA-DRB1 the notorious gene in the mosaic of autoimmunity', Immunologic Research, vol. 65, no. 1, pp. 82-98. https://doi.org/10.1007/s12026-016-8817-7

HLA-DRB1 the notorious gene in the mosaic of autoimmunity. / Arango, María Teresa; Perricone, Carlo; Kivity, Shaye; Cipriano, Enrica; Ceccarelli, Fulvia; Valesini, Guido; Shoenfeld, Yehuda.

In: Immunologic Research, Vol. 65, No. 1, 01.02.2017, p. 82-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA-DRB1 the notorious gene in the mosaic of autoimmunity

AU - Arango, María Teresa

AU - Perricone, Carlo

AU - Kivity, Shaye

AU - Cipriano, Enrica

AU - Ceccarelli, Fulvia

AU - Valesini, Guido

AU - Shoenfeld, Yehuda

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition.

AB - The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition.

UR - http://www.scopus.com/inward/record.url?scp=84978763593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978763593&partnerID=8YFLogxK

U2 - 10.1007/s12026-016-8817-7

DO - 10.1007/s12026-016-8817-7

M3 - Article

C2 - 27435705

AN - SCOPUS:84978763593

VL - 65

SP - 82

EP - 98

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 1

ER -

Arango MT, Perricone C, Kivity S, Cipriano E, Ceccarelli F, Valesini G et al. HLA-DRB1 the notorious gene in the mosaic of autoimmunity. Immunologic Research. 2017 Feb 1;65(1):82-98. https://doi.org/10.1007/s12026-016-8817-7