HLA-DR and DQB1 gene polymorphism in the North-western Colombian population

P. A. Correa; W. C. Whitworth; T. Kuffner; J. McNicholl; J. M. Anaya

doi:10.1034/j.1399-0039.2002.590515.x

HLA-DR and DQB1 gene polymorphism in the North-western Colombian population

P. A. Correa, W. C. Whitworth, T. Kuffner, J. McNicholl, J. M. Anaya

Research output: Contribution to journal › Research Article › peer-review

15 Scopus citations

Abstract

HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north-west Colombia (Medellin) inhabited by the "Paisa", a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA-DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07-DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA-DRB1 and DQB1 locus were in Hardy-Weinberg equilibrium.

Original language	English (US)
Pages (from-to)	436-439
Number of pages	4
Journal	Tissue Antigens
Volume	59
Issue number	5
DOIs	https://doi.org/10.1034/j.1399-0039.2002.590515.x
State	Published - 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1034/j.1399-0039.2002.590515.x

Cite this

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title = "HLA-DR and DQB1 gene polymorphism in the North-western Colombian population",

abstract = "HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north-west Colombia (Medellin) inhabited by the {"}Paisa{"}, a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA-DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07-DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA-DRB1 and DQB1 locus were in Hardy-Weinberg equilibrium.",

author = "Correa, {P. A.} and Whitworth, {W. C.} and T. Kuffner and J. McNicholl and Anaya, {J. M.}",

year = "2002",

doi = "10.1034/j.1399-0039.2002.590515.x",

language = "English (US)",

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TY - JOUR

T1 - HLA-DR and DQB1 gene polymorphism in the North-western Colombian population

AU - Correa, P. A.

AU - Whitworth, W. C.

AU - Kuffner, T.

AU - McNicholl, J.

AU - Anaya, J. M.

PY - 2002

Y1 - 2002

N2 - HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north-west Colombia (Medellin) inhabited by the "Paisa", a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA-DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07-DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA-DRB1 and DQB1 locus were in Hardy-Weinberg equilibrium.

AB - HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north-west Colombia (Medellin) inhabited by the "Paisa", a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA-DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07-DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA-DRB1 and DQB1 locus were in Hardy-Weinberg equilibrium.

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M3 - Research Article

C2 - 12144632

AN - SCOPUS:0036024570

SN - 0001-2815

VL - 59

SP - 436

EP - 439

JO - Tissue Antigens

JF - Tissue Antigens

IS - 5

ER -

HLA-DR and DQB1 gene polymorphism in the North-western Colombian population

Abstract

All Science Journal Classification (ASJC) codes

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