HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies

Paola Cruz-Tapias, Adriana Rojas-Villarraga, Shannon Maier-Moore, Juan Manuel Anaya

Research output: Contribution to journalLiterature review

75 Citations (Scopus)

Abstract

The aim of this work was to identify common HLA Class II alleles contributing to primary Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological implications through a binding prediction approach of peptides from major pSS auto-antigens. Case-control studies on HLA-DQ and HLA-DR in pSS were searched in various literature databases through April 2011 by a systematic review. The effect summary odds ratios and 95% confidence intervals were obtained by means of the random effect model. A total of 1166 cases and 6470 controls from 23 studies were analyzed. At the allelic level, DQA1 *05:01, DQB1 *02:01, and DRB1 *03:01 alleles were found to be risk factors for disease. Conversely, the DQA1 *02:01, DQA1 *03:01 and DQB1 *05:01 alleles were protective factors. The current study stresses the significant size effect HLA exhibits in the development of pSS. Analysis of susceptibility and protective alleles revealed physicochemical differences in critical amino acids located within the antigen-binding groove of DRβ, DQα and DQβ chains, allowing us to infer a mechanistic approach to understand the role of HLA in pSS and other autoimmune diseases. © 2011 Elsevier B.V.
Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalAutoimmunity Reviews
DOIs
StatePublished - Feb 1 2012

Fingerprint

Sjogren's Syndrome
Meta-Analysis
Alleles
HLA-DQ Antigens
Antigens
HLA-DR Antigens
Autoimmune Diseases
Case-Control Studies
Odds Ratio
Databases
Confidence Intervals
Amino Acids
Peptides

Cite this

Cruz-Tapias, Paola ; Rojas-Villarraga, Adriana ; Maier-Moore, Shannon ; Anaya, Juan Manuel. / HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. In: Autoimmunity Reviews. 2012 ; pp. 281-287.
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abstract = "The aim of this work was to identify common HLA Class II alleles contributing to primary Sj{\"o}gren's syndrome (pSS) susceptibility worldwide and to analyze their biological implications through a binding prediction approach of peptides from major pSS auto-antigens. Case-control studies on HLA-DQ and HLA-DR in pSS were searched in various literature databases through April 2011 by a systematic review. The effect summary odds ratios and 95{\%} confidence intervals were obtained by means of the random effect model. A total of 1166 cases and 6470 controls from 23 studies were analyzed. At the allelic level, DQA1 *05:01, DQB1 *02:01, and DRB1 *03:01 alleles were found to be risk factors for disease. Conversely, the DQA1 *02:01, DQA1 *03:01 and DQB1 *05:01 alleles were protective factors. The current study stresses the significant size effect HLA exhibits in the development of pSS. Analysis of susceptibility and protective alleles revealed physicochemical differences in critical amino acids located within the antigen-binding groove of DRβ, DQα and DQβ chains, allowing us to infer a mechanistic approach to understand the role of HLA in pSS and other autoimmune diseases. {\circledC} 2011 Elsevier B.V.",
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HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. / Cruz-Tapias, Paola; Rojas-Villarraga, Adriana; Maier-Moore, Shannon; Anaya, Juan Manuel.

In: Autoimmunity Reviews, 01.02.2012, p. 281-287.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies

AU - Cruz-Tapias, Paola

AU - Rojas-Villarraga, Adriana

AU - Maier-Moore, Shannon

AU - Anaya, Juan Manuel

PY - 2012/2/1

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N2 - The aim of this work was to identify common HLA Class II alleles contributing to primary Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological implications through a binding prediction approach of peptides from major pSS auto-antigens. Case-control studies on HLA-DQ and HLA-DR in pSS were searched in various literature databases through April 2011 by a systematic review. The effect summary odds ratios and 95% confidence intervals were obtained by means of the random effect model. A total of 1166 cases and 6470 controls from 23 studies were analyzed. At the allelic level, DQA1 *05:01, DQB1 *02:01, and DRB1 *03:01 alleles were found to be risk factors for disease. Conversely, the DQA1 *02:01, DQA1 *03:01 and DQB1 *05:01 alleles were protective factors. The current study stresses the significant size effect HLA exhibits in the development of pSS. Analysis of susceptibility and protective alleles revealed physicochemical differences in critical amino acids located within the antigen-binding groove of DRβ, DQα and DQβ chains, allowing us to infer a mechanistic approach to understand the role of HLA in pSS and other autoimmune diseases. © 2011 Elsevier B.V.

AB - The aim of this work was to identify common HLA Class II alleles contributing to primary Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological implications through a binding prediction approach of peptides from major pSS auto-antigens. Case-control studies on HLA-DQ and HLA-DR in pSS were searched in various literature databases through April 2011 by a systematic review. The effect summary odds ratios and 95% confidence intervals were obtained by means of the random effect model. A total of 1166 cases and 6470 controls from 23 studies were analyzed. At the allelic level, DQA1 *05:01, DQB1 *02:01, and DRB1 *03:01 alleles were found to be risk factors for disease. Conversely, the DQA1 *02:01, DQA1 *03:01 and DQB1 *05:01 alleles were protective factors. The current study stresses the significant size effect HLA exhibits in the development of pSS. Analysis of susceptibility and protective alleles revealed physicochemical differences in critical amino acids located within the antigen-binding groove of DRβ, DQα and DQβ chains, allowing us to infer a mechanistic approach to understand the role of HLA in pSS and other autoimmune diseases. © 2011 Elsevier B.V.

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