High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

Alex J. Forero; Marina Muñoz; Milena Camargo; Sara C. Soto-De León; Dora I. Ríos-Chaparro; Claudia Birchenall; Darío Pinilla; Juan Mauricio Pardo Oviedo; Diego F. Josa; Manuel A. Patarroyo; Juan D. Ramírez

doi:10.1186/s13099-019-0308-7

High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

Alex J. Forero, Marina Muñoz, Milena Camargo, Sara C. Soto-De León, Dora I. Ríos-Chaparro, Claudia Birchenall, Darío Pinilla, Juan Mauricio Pardo Oviedo, Diego F. Josa, Manuel A. Patarroyo, Juan D. Ramírez

Research output: Contribution to journal › Research Article › peer-review

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Abstract

Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

Original language	English (US)
Article number	27
Journal	Gut Pathogens
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13099-019-0308-7
State	Published - Jun 3 2019

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Parasitology
Microbiology
Gastroenterology
Virology
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Forero, A. J., Muñoz, M., Camargo, M., Soto-De León, S. C., Ríos-Chaparro, D. I., Birchenall, C., Pinilla, D., Pardo Oviedo, J. M., Josa, D. F., Patarroyo, M. A., & Ramírez, J. D. (2019). High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. Gut Pathogens, 11(1), Article 27. https://doi.org/10.1186/s13099-019-0308-7

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title = "High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogot{\'a}, Colombia",

abstract = "Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogot{\'a}, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.",

author = "Forero, {Alex J.} and Marina Mu{\~n}oz and Milena Camargo and {Soto-De Le{\'o}n}, {Sara C.} and R{\'i}os-Chaparro, {Dora I.} and Claudia Birchenall and Dar{\'i}o Pinilla and {Pardo Oviedo}, {Juan Mauricio} and Josa, {Diego F.} and Patarroyo, {Manuel A.} and Ram{\'i}rez, {Juan D.}",

year = "2019",

month = jun,

day = "3",

doi = "10.1186/s13099-019-0308-7",

language = "English (US)",

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Forero, AJ, Muñoz, M, Camargo, M, Soto-De León, SC, Ríos-Chaparro, DI, Birchenall, C, Pinilla, D, Pardo Oviedo, JM, Josa, DF, Patarroyo, MA & Ramírez, JD 2019, 'High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia', Gut Pathogens, vol. 11, no. 1, 27. https://doi.org/10.1186/s13099-019-0308-7

High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. / Forero, Alex J.; Muñoz, Marina; Camargo, Milena et al.
In: Gut Pathogens, Vol. 11, No. 1, 27, 03.06.2019.

Research output: Contribution to journal › Research Article › peer-review

TY - JOUR

T1 - High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

AU - Forero, Alex J.

AU - Muñoz, Marina

AU - Camargo, Milena

AU - Soto-De León, Sara C.

AU - Ríos-Chaparro, Dora I.

AU - Birchenall, Claudia

AU - Pinilla, Darío

AU - Pardo Oviedo, Juan Mauricio

AU - Josa, Diego F.

AU - Patarroyo, Manuel A.

AU - Ramírez, Juan D.

PY - 2019/6/3

Y1 - 2019/6/3

N2 - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

AB - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

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U2 - 10.1186/s13099-019-0308-7

DO - 10.1186/s13099-019-0308-7

M3 - Research Article

C2 - 31171939

AN - SCOPUS:85066861681

SN - 1757-4749

VL - 11

JO - Gut Pathogens

JF - Gut Pathogens

IS - 1

M1 - 27

ER -

High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

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