Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain)

Ana María Pedraza-Flechas, Luis García-Comas, María Ordobás-Gavín, Juan Carlos Sanz-Moreno, Belén Ramos-Blázquez, Jenaro Astray-Mochales, Santiago Moreno-Guillén

Research output: Contribution to journalResearch Articlepeer-review

5 Scopus citations


Objective: To estimate the prevalence of hepatitis B virus (HBV) infection and vaccine-induced immunity in the region of Madrid, and to analyze their evolution over time. Methods: An observational, analytical, cross-sectional study was carried out in the population aged 16-80 years between 2008 and 2009. This was the last of four seroprevalence surveys in the region of Madrid. The prevalence of HBV infection and vaccine-induced immunity was estimated using multivariate logistic models and were compared with the prevalences in the 1989, 1993 and 1999 surveys. Results: In the population aged 16-80 years, the prevalence of HBV infection was 11.0% (95% CI: 9.8-12.3) and that of chronic infection was 0.7% (95% CI: 0.5-1.1). The prevalence of vaccine-induced immunity in the population aged 16-20 years was 73.0% (95% CI: 70.0-76.0). Compared with previous surveys, there was a decrease in the prevalence of HBV infection. Conclusions: Based on the prevalence of chronic infection (<1%), Madrid is a region with low HBV endemicity. Preventive strategies against HBV should especially target the immigrant population.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalGaceta Sanitaria
Issue number6
StatePublished - 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain)'. Together they form a unique fingerprint.

Cite this