Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies

Alexander J. Davies; Cinta Lleixà; Ana M. Siles; Dawn S. Gourlay; Georgina Berridge; Wanwisa Dejnirattisai; Heily Carolina Ramirez Santana; Juan-Manuel Anaya; Andrew K. Falconar; Claudia M. Romero-Vivas; Lyda Osorio; Beatriz Parra; Gavin R. Screaton; Juthathip Mongkolsapaya; Roman Fischer; Carlos A. Pardo; Susan K. Halstead; Hugh J Willison; Luis Querol; Simon Rinaldi

doi:10.1212/NXI.0000000000200047

Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies

Alexander J. Davies
, Cinta Lleixà
, Ana M. Siles
, Dawn S. Gourlay
, Georgina Berridge
, Wanwisa Dejnirattisai
, Heily Carolina Ramirez Santana
, Juan-Manuel Anaya
, Andrew K. Falconar
, Claudia M. Romero-Vivas
, Lyda Osorio
, Beatriz Parra
, Gavin R. Screaton
, Juthathip Mongkolsapaya
, Roman Fischer
, Carlos A. Pardo
, Susan K. Halstead
, Hugh J Willison
, Luis Querol
, Simon Rinaldi

Research output: Contribution to Journal › Research Article › peer-review

17 Scopus citations

Abstract

Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV with and without GBS.

Translated title of the contribution	El síndrome de Guillain-Barré tras la infección por el virus del Zika se asocia a un espectro diverso de anticuerpos reactivos contra los nervios periféricos
Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Neurology: Neuroimmunology and NeuroInflammation
Volume	10
Issue number	1
DOIs	https://doi.org/10.1212/NXI.0000000000200047
State	Published - Nov 21 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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10.1212/NXI.0000000000200047

Cite this

Davies, A. J., Lleixà, C., Siles, A. M., Gourlay, D. S., Berridge, G., Dejnirattisai, W., Ramirez Santana, H. C., Anaya, J.-M., Falconar, A. K., Romero-Vivas, C. M., Osorio, L., Parra, B., Screaton, G. R., Mongkolsapaya, J., Fischer, R., Pardo, C. A., Halstead, S. K., Willison, H. J., Querol, L., & Rinaldi, S. (2022). Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies. Neurology: Neuroimmunology and NeuroInflammation, 10(1), 1-14. https://doi.org/10.1212/NXI.0000000000200047

@article{116701fb3a6d4ba58bef53f607d5667b,

title = "Guillain-Barr{\'e} Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies",

abstract = "Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barr{\'e} syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV with and without GBS.",

author = "Davies, \{Alexander J.\} and Cinta Lleix{\`a} and Siles, \{Ana M.\} and Gourlay, \{Dawn S.\} and Georgina Berridge and Wanwisa Dejnirattisai and \{Ramirez Santana\}, \{Heily Carolina\} and Juan-Manuel Anaya and Falconar, \{Andrew K.\} and Romero-Vivas, \{Claudia M.\} and Lyda Osorio and Beatriz Parra and Screaton, \{Gavin R.\} and Juthathip Mongkolsapaya and Roman Fischer and Pardo, \{Carlos A.\} and Halstead, \{Susan K.\} and Willison, \{Hugh J\} and Luis Querol and Simon Rinaldi",

year = "2022",

month = nov,

day = "21",

doi = "10.1212/NXI.0000000000200047",

language = "English (US)",

volume = "10",

pages = "1--14",

journal = "Neurology: Neuroimmunology and NeuroInflammation",

issn = "2332-7812",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

Davies, AJ, Lleixà, C, Siles, AM, Gourlay, DS, Berridge, G, Dejnirattisai, W, Ramirez Santana, HC, Anaya, J-M, Falconar, AK, Romero-Vivas, CM, Osorio, L, Parra, B, Screaton, GR, Mongkolsapaya, J, Fischer, R, Pardo, CA, Halstead, SK, Willison, HJ, Querol, L & Rinaldi, S 2022, 'Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies', Neurology: Neuroimmunology and NeuroInflammation, vol. 10, no. 1, pp. 1-14. https://doi.org/10.1212/NXI.0000000000200047

TY - JOUR

T1 - Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies

AU - Davies, Alexander J.

AU - Lleixà, Cinta

AU - Siles, Ana M.

AU - Gourlay, Dawn S.

AU - Berridge, Georgina

AU - Dejnirattisai, Wanwisa

AU - Ramirez Santana, Heily Carolina

AU - Anaya, Juan-Manuel

AU - Falconar, Andrew K.

AU - Romero-Vivas, Claudia M.

AU - Osorio, Lyda

AU - Parra, Beatriz

AU - Screaton, Gavin R.

AU - Mongkolsapaya, Juthathip

AU - Fischer, Roman

AU - Pardo, Carlos A.

AU - Halstead, Susan K.

AU - Willison, Hugh J

AU - Querol, Luis

AU - Rinaldi, Simon

PY - 2022/11/21

Y1 - 2022/11/21

N2 - Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV with and without GBS.

AB - Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV with and without GBS.

U2 - 10.1212/NXI.0000000000200047

DO - 10.1212/NXI.0000000000200047

M3 - Research Article

C2 - 36411078

SN - 2332-7812

VL - 10

SP - 1

EP - 14

JO - Neurology: Neuroimmunology and NeuroInflammation

JF - Neurology: Neuroimmunology and NeuroInflammation

IS - 1

ER -

Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies

Abstract

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