Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies

Alexander J. Davies, Cinta Lleixà, Ana M. Siles, Dawn S. Gourlay, Georgina Berridge, Wanwisa Dejnirattisai, Heily Carolina Ramirez Santana, Juan-Manuel Anaya, Andrew K. Falconar, Claudia M. Romero-Vivas, Lyda Osorio, Beatriz Parra, Gavin R. Screaton, Juthathip Mongkolsapaya, Roman Fischer, Carlos A. Pardo, Susan K. Halstead, Hugh J Willison, Luis Querol, Simon Rinaldi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV with and without GBS.
Translated title of the contributionEl síndrome de Guillain-Barré tras la infección por el virus del Zika se asocia a un espectro diverso de anticuerpos reactivos contra los nervios periféricos
Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalNeurology: Neuroimmunology and NeuroInflammation
Volume10
Issue number1
DOIs
StatePublished - Nov 21 2022

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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