Genetic and molecular aspects of drug-induced QT interval prolongation

Daniela Baracaldo-Santamaría, Kevin Llinás-Caballero, Julián Miguel Corso-Ramirez, Carlos Martín Restrepo, Camilo Alberto Dominguez-Dominguez, Dora Janeth Fonseca-Mendoza, Carlos Alberto Calderon - Ospina

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations
13 Downloads (Pure)


Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.

Translated title of the contributionAspectos genéticos y moleculares de la prolongación del intervalo QT inducida por fármacos
Original languageEnglish (US)
Article number8090
JournalInternational Journal of Molecular Sciences
Issue number15
StatePublished - Jul 28 2021

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Genetic and molecular aspects of drug-induced QT interval prolongation'. Together they form a unique fingerprint.

Cite this