Functionally relevant proteins in Plasmodium falciparum host cell invasion

Manuel Elkin Patarroyo, Martha P. Alba, Rocío Rojas-Luna, Adriana Bermudez, Jorge Aza-Conde

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function.

Original languageEnglish (US)
Pages (from-to)131-155
Number of pages25
JournalImmunotherapy
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology

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