TY - JOUR
T1 - Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction
AU - Messinger, John
AU - Lopez-Guzman, Silvia
AU - Banavar, Nidhi
AU - Rotrosen, John
AU - Glimcher, Paul
AU - Konova, Anna
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: How craving and mood states (e.g., stress,
boredom) bias behavior toward rewarding but less adaptive
alternatives and away from an individual’s health goals is
poorly understood, yet play a critical role in addiction and
eating disorders. Here we test the hypothesis that underlying
this bias is a state-dependent increase in the subjective value
of these rewarding but less-adaptive choice alternatives.
Methods: 27 treatment-seeking opioid users completed a
decision-making task that probed their momentary willingness-to-pay
for a range of real opioid useerelated and
eunrelated goods, a quantitative measure of their value.
These goods were identified as most (least) related to an
individual subject’s use. To capture how dynamics in
spontaneous opioid craving and mood affect subjective
valuation, patients completed the task over 2 days while
continuously reporting their current opioid craving, stress
level, boredom, and happiness. Skin conductance and facial
EMG were measured concurrently as indices of arousal and
valence, respectively.
Results: Subjects were willing to pay more specifically for
personalized opioid-related goods when experiencing higher
craving, stress, and boredom and lower happiness (subjective
state level X opioid-relatedness: P<0.016). Despite mild
correlation across subjective states (R¼j0.14e0.51j), the
effects of each on valuation were largely independent,
particularly of craving and stress. Analysis of physiological
data is ongoing, but we hypothesize these data will serve as
auxiliary, objective measures of how subjective states bias
valuation.
Conclusions: These data suggest craving and stress both
enhance the value of less-adaptive choice alternatives when
these are immediately rewarding, potentially reflecting a
compensatory mechanism aimed at buffering these states
AB - Background: How craving and mood states (e.g., stress,
boredom) bias behavior toward rewarding but less adaptive
alternatives and away from an individual’s health goals is
poorly understood, yet play a critical role in addiction and
eating disorders. Here we test the hypothesis that underlying
this bias is a state-dependent increase in the subjective value
of these rewarding but less-adaptive choice alternatives.
Methods: 27 treatment-seeking opioid users completed a
decision-making task that probed their momentary willingness-to-pay
for a range of real opioid useerelated and
eunrelated goods, a quantitative measure of their value.
These goods were identified as most (least) related to an
individual subject’s use. To capture how dynamics in
spontaneous opioid craving and mood affect subjective
valuation, patients completed the task over 2 days while
continuously reporting their current opioid craving, stress
level, boredom, and happiness. Skin conductance and facial
EMG were measured concurrently as indices of arousal and
valence, respectively.
Results: Subjects were willing to pay more specifically for
personalized opioid-related goods when experiencing higher
craving, stress, and boredom and lower happiness (subjective
state level X opioid-relatedness: P<0.016). Despite mild
correlation across subjective states (R¼j0.14e0.51j), the
effects of each on valuation were largely independent,
particularly of craving and stress. Analysis of physiological
data is ongoing, but we hypothesize these data will serve as
auxiliary, objective measures of how subjective states bias
valuation.
Conclusions: These data suggest craving and stress both
enhance the value of less-adaptive choice alternatives when
these are immediately rewarding, potentially reflecting a
compensatory mechanism aimed at buffering these states
U2 - https://doi.org/10.1016/j.biopsych.2018.02.602
DO - https://doi.org/10.1016/j.biopsych.2018.02.602
M3 - Meeting Abstract
VL - 83
SP - S232-S233
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 9
ER -