First colombian multicentric newborn screening for congenital toxoplasmosis

Jorge Enrique Gómez-Marin, Alejandra de-la-Torre, Edith Angel-Muller, Jorge Rubio, Jaime Arenas, Elkin Osorio, Lilian Nuñez, Lyda Pinzon, Luis Carlos Mendez-Cordoba, Agustin Bustos, Isabel de-la-Hoz, Pedro Silva, Monica Beltran, Leonor Chacon, Martha Marrugo, Cristina Manjarres, Hernando Baquero, Fabiana Lora, Elizabeth Torres, Oscar Elias ZuluagaMonica Estrada, Lacides Moscote, Myriam Teresa Silva, Raul Rivera, Angie Molina, Shirley Najera, Antonio Sanabria, Maria Luisa Ramirez, Claudia Alarcon, Natalia Restrepo, Alejandra Falla, Tailandia Rodriguez, Giovanny Castaño

Research output: Contribution to journalResearch Articlepeer-review

79 Scopus citations


Aims: To determine the incidence of congenital toxoplasmosis in Colombian newborns from 19 hospital or maternal child health services from seven different cities of five natural geographic regions (Caribbean, Central, Andean, Amazonia and Eastern). Materials and Methods: We collected 15,333 samples from umbilical cord blood between the period of March 2009 to May 2010 in 19 different hospitals and maternal-child health services from seven different cities. We applied an IgM ELISA assay (Vircell, Spain) to determine the frequency of IgM anti Toxoplasma. The results in blood cord samples were confirmed either by western blot and repeated ELISA IgM assay. In a sub-sample of 1,613 children that were negative by the anti-Toxoplasma IgM assay, the frequency of specific anti-Toxoplasma IgA by the ISAGA assay was determined. All children with positive samples by IgM, IgA, clinical diagnosis or treatment during pregnancy were recalled for confirmatory tests after day 10 of life. Results: 61 positive samples for specific IgM (0.39%) and 9 positives for IgA (0.5%) were found. 143 questionnaires were positive for a clinical diagnosis or treatment for toxoplasmosis during pregnancy. 109 out of the 218 children that had some of the criteria for postnatal confirmatory tests were followed. Congenital toxoplasmosis infection was confirmed in 15 children: 7 were symptomatic, and three of them died before the first month of life (20% of lethality). A significant correlation was found between a high incidence of markers for congenital toxoplasmosis and higher mean annual rainfall for the city. Conclusions: Incidence for congenital toxoplasmosis is significantly different between hospitals or maternal child health services from different cities in Colombia. Mean annual rainfall was correlated with incidence of congenital toxoplasmosis.
Translated title of the contributionPrimer screening multicéntrico colombiano de recién nacidos para toxoplasmosis congénita
Original languageEnglish (US)
Article numbere1195
Pages (from-to)1-10
Number of pages10
JournalPLoS Neglected Tropical Diseases
Issue number5
StatePublished - May 1 2011


Dive into the research topics of 'First colombian multicentric newborn screening for congenital toxoplasmosis'. Together they form a unique fingerprint.

Cite this