Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

Keyphrases

• Systemic Lupus Erythematosus 100%
• Fine Mapping 100%
• IL-1 Receptor-associated Kinase 1 (IRAK1) 100%
• Methyl-CpG-binding Protein 2 (MeCP2) 100%
• Xq28 100%
• SNP 37%
• Causal Variants 37%
• High-risk HPV 25%
• Meta-analysis 12%
• Healthy Controls 12%
• Hispanic 12%
• African Ancestry 12%
• Linkage Disequilibrium 12%
• European American 12%
• In Vitro Activity 12%
• Control Subjects 12%
• Risk Allele 12%
• MRNA Level 12%
• Genetic Association Studies 12%
• Amino Acid Substitution 12%
• Systemic Lupus Erythematosus Patient 12%
• Risk Loci 12%
• Association Signal 12%
• Adjacent Genes 12%
• HCFC1 12%
• L1 Cell Adhesion Molecule (L1CAM) 12%
• Common Risks 12%
• Nuclear factor-κB 12%
• ARHGAP4 12%
• AVPR2 12%
• NAA10 12%

Biochemistry, Genetics and Molecular Biology

• MECP2 100%
• IRAK1 100%
• Single Nucleotide Polymorphism 37%
• Haplotype 12%
• Allele 12%
• Genotyping 12%
• Messenger RNA 12%
• Gene Linkage Disequilibrium 12%
• Genetic Association Study 12%
• Amino Acid Substitution 12%

Immunology and Microbiology

• Systemic Lupus Erythematosus 100%
• IRAK1 100%
• Single Nucleotide Polymorphism 37%
• Allele 12%
• Haplotype 12%
• Gene Linkage Disequilibrium 12%
• Genetic Association Study 12%
• Amino Acid Substitution 12%