Fatal disseminated cryptococcus gattii infection in New Mexico

Carla J. Walraven; Wendy Gerstein; Sarah E. Hardison; Floyd Wormley; Shawn R. Lockhart; Julie R. Harris; Annette Fothergill; Brian Wickes; Julie Gober-Wilcox; Larry Massie; T. S.Neil Ku; Carolina Firacative; Wieland Meyer; Samuel A. Lee

doi:10.1371/journal.pone.0028625

Fatal disseminated cryptococcus gattii infection in New Mexico

Carla J. Walraven, Wendy Gerstein, Sarah E. Hardison, Floyd Wormley, Shawn R. Lockhart, Julie R. Harris, Annette Fothergill, Brian Wickes, Julie Gober-Wilcox, Larry Massie, T. S.Neil Ku, Carolina Firacative, Wieland Meyer, Samuel A. Lee

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

Original language	English (US)
Article number	e28625
Journal	PLOS ONE
Volume	6
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0028625
State	Published - Dec 14 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General

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abstract = "We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.",

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AU - Gerstein, Wendy

AU - Hardison, Sarah E.

AU - Wormley, Floyd

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AU - Harris, Julie R.

AU - Fothergill, Annette

AU - Wickes, Brian

AU - Gober-Wilcox, Julie

AU - Massie, Larry

AU - Ku, T. S.Neil

AU - Firacative, Carolina

AU - Meyer, Wieland

AU - Lee, Samuel A.

PY - 2011/12/14

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AB - We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

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Fatal disseminated cryptococcus gattii infection in New Mexico

Abstract

All Science Journal Classification (ASJC) codes

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