Fatal co-infection by multiple pathogens in an indigenous woman with autoimmune hemolytic anemia and tuberculosis: a case report

Bryan Tabares, Alisson Dayana Sarmiento-Suárez, Óscar Gil, Juan Camilo Hernández-Pabón, Carolina Firacative

Research output: Contribution to journalResearch Articlepeer-review

Abstract

BACKGROUND: Tuberculosis (TB), one of the leading causes of death worldwide, has a higher incidence among indigenous people. Albeit uncommon, autoimmune hemolytic anemia (AIHA) has been deemed a risk condition to develop mycobacterial infection, as a result of the immunosuppressive treatments. TB, in turn, can be a predisposing factor for secondary infections. CASE PRESENTATION: Here we present a case of a 28-year-old indigenous woman from Colombia, previously diagnosed with AIHA and pulmonary TB. Despite various treatments, therapies and medical interventions, the patient died after severe medullary aplasia of multiple causes, including secondary myelotoxicity by immunosuppressive therapy and secondary disseminated infections, underlining infection by Staphylococcus aureus, Klebsiella pneumoniae and Candida glabrata, which were identified as drug-resistant microorganisms. Together, this led to significant clinical complications. Invasive aspergillosis was diagnosed at autopsy. CONCLUSIONS: This report presents a rarely finding of AIHA followed by TB, and highlights the great challenges of dealing with co-infections, particularly by drug resistant pathogens. It also aims to spur governments and public health authorities to focus attention in the prevention, screening and management of TB, especially among vulnerable communities, such as indigenous people.

Translated title of the contributionCoinfección mortal por múltiples patógenos en una mujer indígena con anemia hemolítica autoinmune y tuberculosis: informe de un caso
Original languageEnglish (US)
Article number645
Pages (from-to)1-6
Number of pages6
JournalBMC Infectious Diseases
Volume24
Issue number1
DOIs
StatePublished - Jun 24 2024

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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