Failure analysis of tevg’s i: Overcoming the initial stages of blood material interaction and stabilization of the immune response

Maria A. Rodriguez-Soto, Natalia Suarez Vargas, Alejandra Riveros, Carolina Muñoz Camargo, Juan C. Cruz, Nestor Sandoval, Juan C. Briceño

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine with the tissue engineered vascular grafts (TEVGs), the cellular response is not yet close to mimicking the biological function of native vessels, and the understanding of the interactions between cells from the blood and the vascular wall with the material in operative conditions is much needed. These interactions change over time after the implantation of the graft. Here we aim to analyze the current knowledge in bio-molecular interactions between blood components, cells and materials that lead either to an early failure or to the stabilization of the vascular graft before the wall regeneration begins.

Original languageEnglish (US)
Article number3140
JournalCells
Volume10
Issue number11
DOIs
StatePublished - Nov 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology

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