Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

Gisele Zandman-Goddard; Yackov Berkun; Ori Barzilai; Mona Boaz; Miri Blank; Maya Ram; Yaniv Sherer; Juan Manuel Anaya; Yehuda Shoenfeld

doi:10.1111/j.1749-6632.2009.04754.x

Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

Gisele Zandman-Goddard
, Yackov Berkun
, Ori Barzilai
, Mona Boaz
, Miri Blank
, Maya Ram
, Yaniv Sherer
, Juan Manuel Anaya
, Yehuda Shoenfeld

urosario

Research output: Chapter in Book/Inform › Conference contribution

84 Scopus citations

Abstract

Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.

Original language	English (US)
Title of host publication	Contemporary Challenges in Autoimmunity
Publisher	Blackwell Publishing, Inc.
Pages	658-663
Number of pages	6
ISBN (Print)	9781573317627
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04754.x
State	Published - Sep 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1173
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2009.04754.x

Cite this

Zandman-Goddard, G., Berkun, Y., Barzilai, O., Boaz, M., Blank, M., Ram, M., Sherer, Y., Anaya, J. M., & Shoenfeld, Y. (2009). Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease. In Contemporary Challenges in Autoimmunity (pp. 658-663). (Annals of the New York Academy of Sciences; Vol. 1173). Blackwell Publishing, Inc.. https://doi.org/10.1111/j.1749-6632.2009.04754.x

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title = "Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease",

abstract = "Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.",

author = "Gisele Zandman-Goddard and Yackov Berkun and Ori Barzilai and Mona Boaz and Miri Blank and Maya Ram and Yaniv Sherer and Anaya, \{Juan Manuel\} and Yehuda Shoenfeld",

year = "2009",

month = sep,

doi = "10.1111/j.1749-6632.2009.04754.x",

language = "English (US)",

isbn = "9781573317627",

series = "Annals of the New York Academy of Sciences",

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}

Zandman-Goddard, G, Berkun, Y, Barzilai, O, Boaz, M, Blank, M, Ram, M, Sherer, Y, Anaya, JM & Shoenfeld, Y 2009, Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease. in Contemporary Challenges in Autoimmunity. Annals of the New York Academy of Sciences, vol. 1173, Blackwell Publishing, Inc., pp. 658-663. https://doi.org/10.1111/j.1749-6632.2009.04754.x

Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease. / Zandman-Goddard, Gisele; Berkun, Yackov; Barzilai, Ori et al.
Contemporary Challenges in Autoimmunity. Blackwell Publishing, Inc., 2009. p. 658-663 (Annals of the New York Academy of Sciences; Vol. 1173).

Research output: Chapter in Book/Inform › Conference contribution

TY - GEN

T1 - Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

AU - Zandman-Goddard, Gisele

AU - Berkun, Yackov

AU - Barzilai, Ori

AU - Boaz, Mona

AU - Blank, Miri

AU - Ram, Maya

AU - Sherer, Yaniv

AU - Anaya, Juan Manuel

AU - Shoenfeld, Yehuda

PY - 2009/9

Y1 - 2009/9

N2 - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.

AB - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.

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AN - SCOPUS:69949178754

SN - 9781573317627

T3 - Annals of the New York Academy of Sciences

SP - 658

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BT - Contemporary Challenges in Autoimmunity

PB - Blackwell Publishing, Inc.

ER -

Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

Abstract

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