TY - GEN
T1 - Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
AU - Zandman-Goddard, Gisele
AU - Berkun, Yackov
AU - Barzilai, Ori
AU - Boaz, Mona
AU - Blank, Miri
AU - Ram, Maya
AU - Sherer, Yaniv
AU - Anaya, Juan Manuel
AU - Shoenfeld, Yehuda
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009/9
Y1 - 2009/9
N2 - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.
AB - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.
UR - http://www.scopus.com/inward/record.url?scp=69949178754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69949178754&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04754.x
DO - 10.1111/j.1749-6632.2009.04754.x
M3 - Conference contribution
C2 - 19758212
AN - SCOPUS:69949178754
SN - 9781573317627
T3 - Annals of the New York Academy of Sciences
SP - 658
EP - 663
BT - Contemporary Challenges in Autoimmunity
PB - Blackwell Publishing, Inc.
ER -