Abstract
Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 424-430 |
| Number of pages | 7 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 58 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Virology
- Parasitology
