Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

L. Franco, L. Najvar, B. L. Gomez, S. Restrepo, J. R. Graybill, A. Restrepo

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

Original languageEnglish (US)
Pages (from-to)424-430
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume58
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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