Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

L. Franco; L. Najvar; B. L. Gomez; S. Restrepo; J. R. Graybill; A. Restrepo

doi:10.4269/ajtmh.1998.58.424

Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

L. Franco, L. Najvar, B. L. Gomez, S. Restrepo, J. R. Graybill, A. Restrepo

Research output: Contribution to journal › Research Article › peer-review

28 Scopus citations

Abstract

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

Original language	English (US)
Pages (from-to)	424-430
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	58
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.1998.58.424
State	Published - 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology
Parasitology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4269/ajtmh.1998.58.424

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abstract = "Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.",

author = "L. Franco and L. Najvar and Gomez, {B. L.} and S. Restrepo and Graybill, {J. R.} and A. Restrepo",

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AU - Gomez, B. L.

AU - Restrepo, S.

AU - Graybill, J. R.

AU - Restrepo, A.

PY - 1998

Y1 - 1998

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AB - Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

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Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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