Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

L. Franco; L. Najvar; B. L. Gomez; S. Restrepo; J. R. Graybill; A. Restrepo

doi:10.4269/ajtmh.1998.58.424

Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

L. Franco, L. Najvar, B. L. Gomez, S. Restrepo, J. R. Graybill, A. Restrepo

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

Original language	English (US)
Pages (from-to)	424-430
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	58
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.1998.58.424
State	Published - 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology
Parasitology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4269/ajtmh.1998.58.424

Cite this

@article{3be58f3c4a2b4177a4566d6778156308,

title = "Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses",

abstract = "Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.",

author = "L. Franco and L. Najvar and Gomez, {B. L.} and S. Restrepo and Graybill, {J. R.} and A. Restrepo",

year = "1998",

doi = "10.4269/ajtmh.1998.58.424",

language = "English (US)",

volume = "58",

pages = "424--430",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "4",

}

TY - JOUR

T1 - Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia

T2 - Measurement of local host responses

AU - Franco, L.

AU - Najvar, L.

AU - Gomez, B. L.

AU - Restrepo, S.

AU - Graybill, J. R.

AU - Restrepo, A.

PY - 1998

Y1 - 1998

N2 - Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

AB - Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-α and transforming growth factor- β. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

UR - http://www.scopus.com/inward/record.url?scp=0031940049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031940049&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.1998.58.424

DO - 10.4269/ajtmh.1998.58.424

M3 - Article

C2 - 9574786

AN - SCOPUS:0031940049

SN - 0002-9637

VL - 58

SP - 424

EP - 430

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 4

ER -

Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: Measurement of local host responses

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this