Exercise dose-response of the V̇ E/V̇CO 2 slope in postmenopausal women in the DREW study

Stephanie A. Anaya, Timothy S. Church, Steven N. Blair, Jonathan N. Myers, Conrad P. Earnest

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: Being overweight/ obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V̇ E/V̇CO 2 slope, which is predictive of mortality in patients with CHF. Although the V̇ E/V̇CO 2 slope is well established in CHF patients, little is known regarding interventions for "at-risk" populations. Methods: We examined the V̇ E/V̇CO 2 slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal̇kg -1wk -1 (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline V̇O 2max. We examined trends in exercise treatment dose versus change in mean V̇ E/V̇CO 2 slope using a linear regression model (KKW vs V̇ E/V̇CO 2 slope) and a linear mixed model. Results: Regression analysis showed a significant trend for a reduction in the V̇ E/V̇CO 2 slope from baseline (mean plusmn; SD: 32.6 plusmn; 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V̇ E/V̇CO 2 slope for the 8-KKW (-1.14; 95% CI, -1.5 to -0.2) and 12-KKW (-1.67; 95% CI, -2.3 to -0.3) groups. No significant effect was noted for the 4-KKW (-0.4; 95% CI, -1.2 to 0.15) group. Conclusion: Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V?E/VCO2 slope in postmenopausal women who exhibit risk factors associated with the development of CHF.

Original languageEnglish (US)
Pages (from-to)971-976
Number of pages6
JournalMedicine and Science in Sports and Exercise
Issue number5
StatePublished - May 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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