Exercise and glucose control in children with insulin resistance: prevalence of non-responders

C. Álvarez, R. Ramírez-Campillo, J. Cano-Montoya, R. Ramírez-Vélez, S. D.R. Harridge, A. M. Alonso-Martínez, M. Izquierdo

Research output: Contribution to journalArticle

Abstract

Background: Exercise training improves cardiometabolic outcomes in ‘mean terms’, but little information is available in children about the impact of the frequency/week and the wide inter-individual variability to exercise training reported in adults. Objectives: We compared the effects of resistance training (RT) and high-intensity interval training (HIT), and ‘high’ and ‘low’ frequency of training/week, for their effectiveness in decreasing insulin resistance (IR) levels in schoolchildren. A second aim was to decscribe and compare the prevalence of non-responders (NRs) between the different frequencies of training protocol. Methods: Fifty-three schoolchildren with IR were randomly assigned into four groups: RT at high frequency (three times/week), HIT at high frequency, RT at a low frequency (two times/week) and HIT at low frequency. The intervention lasted 6 weeks. Blood samples and body composition, blood pressure and performance measurements were taken before and after the intervention. Results: The prevalence of NRs was similar between the RTHF and HITHF (25.0% vs. 25.0%, P > 0.05) and RTLF and HITLF groups (20.0% vs. 46.6%, P = 0.174) for decreasing homeostasis model assessment of IR. However, significant differences in the prevalence of NRs were detected between RTHF and HITHF groups in fasting glucose (FGL) (18.7% vs. 58.3%, P < 0.031). Conclusions: Both RT and HIT improves the glucose control parameters in schoolchildren over 6 weeks, but only HIT is independent of a high or low frequency of training/week. The prevalence of NRs is similar for decreasing homeostasis model assessment of IR comparing each exercise mode in high vs. low frequency/week. However, both high- and low-frequency RT and HIT results in differences in the prevalence of NRs for FGL and other cardiometabolic and performance outcomes.

Original languageEnglish (US)
JournalPediatric obesity
DOIs
StatePublished - Sep 11 2018

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Álvarez, C., Ramírez-Campillo, R., Cano-Montoya, J., Ramírez-Vélez, R., Harridge, S. D. R., Alonso-Martínez, A. M., & Izquierdo, M. (2018). Exercise and glucose control in children with insulin resistance: prevalence of non-responders. Pediatric obesity. https://doi.org/10.1111/ijpo.12437
Álvarez, C. ; Ramírez-Campillo, R. ; Cano-Montoya, J. ; Ramírez-Vélez, R. ; Harridge, S. D.R. ; Alonso-Martínez, A. M. ; Izquierdo, M. / Exercise and glucose control in children with insulin resistance : prevalence of non-responders. In: Pediatric obesity. 2018.
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abstract = "Background: Exercise training improves cardiometabolic outcomes in ‘mean terms’, but little information is available in children about the impact of the frequency/week and the wide inter-individual variability to exercise training reported in adults. Objectives: We compared the effects of resistance training (RT) and high-intensity interval training (HIT), and ‘high’ and ‘low’ frequency of training/week, for their effectiveness in decreasing insulin resistance (IR) levels in schoolchildren. A second aim was to decscribe and compare the prevalence of non-responders (NRs) between the different frequencies of training protocol. Methods: Fifty-three schoolchildren with IR were randomly assigned into four groups: RT at high frequency (three times/week), HIT at high frequency, RT at a low frequency (two times/week) and HIT at low frequency. The intervention lasted 6 weeks. Blood samples and body composition, blood pressure and performance measurements were taken before and after the intervention. Results: The prevalence of NRs was similar between the RTHF and HITHF (25.0{\%} vs. 25.0{\%}, P > 0.05) and RTLF and HITLF groups (20.0{\%} vs. 46.6{\%}, P = 0.174) for decreasing homeostasis model assessment of IR. However, significant differences in the prevalence of NRs were detected between RTHF and HITHF groups in fasting glucose (FGL) (18.7{\%} vs. 58.3{\%}, P < 0.031). Conclusions: Both RT and HIT improves the glucose control parameters in schoolchildren over 6 weeks, but only HIT is independent of a high or low frequency of training/week. The prevalence of NRs is similar for decreasing homeostasis model assessment of IR comparing each exercise mode in high vs. low frequency/week. However, both high- and low-frequency RT and HIT results in differences in the prevalence of NRs for FGL and other cardiometabolic and performance outcomes.",
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Álvarez, C, Ramírez-Campillo, R, Cano-Montoya, J, Ramírez-Vélez, R, Harridge, SDR, Alonso-Martínez, AM & Izquierdo, M 2018, 'Exercise and glucose control in children with insulin resistance: prevalence of non-responders', Pediatric obesity. https://doi.org/10.1111/ijpo.12437

Exercise and glucose control in children with insulin resistance : prevalence of non-responders. / Álvarez, C.; Ramírez-Campillo, R.; Cano-Montoya, J.; Ramírez-Vélez, R.; Harridge, S. D.R.; Alonso-Martínez, A. M.; Izquierdo, M.

In: Pediatric obesity, 11.09.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise and glucose control in children with insulin resistance

T2 - prevalence of non-responders

AU - Álvarez, C.

AU - Ramírez-Campillo, R.

AU - Cano-Montoya, J.

AU - Ramírez-Vélez, R.

AU - Harridge, S. D.R.

AU - Alonso-Martínez, A. M.

AU - Izquierdo, M.

PY - 2018/9/11

Y1 - 2018/9/11

N2 - Background: Exercise training improves cardiometabolic outcomes in ‘mean terms’, but little information is available in children about the impact of the frequency/week and the wide inter-individual variability to exercise training reported in adults. Objectives: We compared the effects of resistance training (RT) and high-intensity interval training (HIT), and ‘high’ and ‘low’ frequency of training/week, for their effectiveness in decreasing insulin resistance (IR) levels in schoolchildren. A second aim was to decscribe and compare the prevalence of non-responders (NRs) between the different frequencies of training protocol. Methods: Fifty-three schoolchildren with IR were randomly assigned into four groups: RT at high frequency (three times/week), HIT at high frequency, RT at a low frequency (two times/week) and HIT at low frequency. The intervention lasted 6 weeks. Blood samples and body composition, blood pressure and performance measurements were taken before and after the intervention. Results: The prevalence of NRs was similar between the RTHF and HITHF (25.0% vs. 25.0%, P > 0.05) and RTLF and HITLF groups (20.0% vs. 46.6%, P = 0.174) for decreasing homeostasis model assessment of IR. However, significant differences in the prevalence of NRs were detected between RTHF and HITHF groups in fasting glucose (FGL) (18.7% vs. 58.3%, P < 0.031). Conclusions: Both RT and HIT improves the glucose control parameters in schoolchildren over 6 weeks, but only HIT is independent of a high or low frequency of training/week. The prevalence of NRs is similar for decreasing homeostasis model assessment of IR comparing each exercise mode in high vs. low frequency/week. However, both high- and low-frequency RT and HIT results in differences in the prevalence of NRs for FGL and other cardiometabolic and performance outcomes.

AB - Background: Exercise training improves cardiometabolic outcomes in ‘mean terms’, but little information is available in children about the impact of the frequency/week and the wide inter-individual variability to exercise training reported in adults. Objectives: We compared the effects of resistance training (RT) and high-intensity interval training (HIT), and ‘high’ and ‘low’ frequency of training/week, for their effectiveness in decreasing insulin resistance (IR) levels in schoolchildren. A second aim was to decscribe and compare the prevalence of non-responders (NRs) between the different frequencies of training protocol. Methods: Fifty-three schoolchildren with IR were randomly assigned into four groups: RT at high frequency (three times/week), HIT at high frequency, RT at a low frequency (two times/week) and HIT at low frequency. The intervention lasted 6 weeks. Blood samples and body composition, blood pressure and performance measurements were taken before and after the intervention. Results: The prevalence of NRs was similar between the RTHF and HITHF (25.0% vs. 25.0%, P > 0.05) and RTLF and HITLF groups (20.0% vs. 46.6%, P = 0.174) for decreasing homeostasis model assessment of IR. However, significant differences in the prevalence of NRs were detected between RTHF and HITHF groups in fasting glucose (FGL) (18.7% vs. 58.3%, P < 0.031). Conclusions: Both RT and HIT improves the glucose control parameters in schoolchildren over 6 weeks, but only HIT is independent of a high or low frequency of training/week. The prevalence of NRs is similar for decreasing homeostasis model assessment of IR comparing each exercise mode in high vs. low frequency/week. However, both high- and low-frequency RT and HIT results in differences in the prevalence of NRs for FGL and other cardiometabolic and performance outcomes.

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Álvarez C, Ramírez-Campillo R, Cano-Montoya J, Ramírez-Vélez R, Harridge SDR, Alonso-Martínez AM et al. Exercise and glucose control in children with insulin resistance: prevalence of non-responders. Pediatric obesity. 2018 Sep 11. https://doi.org/10.1111/ijpo.12437