Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

Antonio García-Hermoso, R. J.M. Ceballos-Ceballos, C. E. Poblete-Aro, A. C. Hackney, J. Mota, R. Ramírez-Vélez

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Background/Objective:Adipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to determine the effectiveness of exercise interventions on adipokines in pediatric obesity.Subjects/Methods:A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin and visfatin) in pediatric obesity (6-18 years old). Fourteen randomized controlled trials (347 youths) were included. Weighted mean difference (WMD) and 95% confidence intervals were calculated.Results:Exercise was associated with a significant increase in adiponectin (WMD=0.882 μg ml -1, 95% CI, 0.271-1.493) but did not alter leptin and resistin level. Likewise, exercise intensity and change in body fat; as well as total exercise program duration, duration of the sessions, and change in body fat all significantly influenced the effect of exercise on adiponectin and leptin, respectively.Conclusions:Exercise seems to increase adiponectin levels in childhood obesity. Our results also suggested that exercise on its own, without the concomitant presence of changes in body composition levels, does not affect leptin levels.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalInternational Journal of Obesity
Issue number4
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


Dive into the research topics of 'Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials'. Together they form a unique fingerprint.

Cite this