Evidencia del comportamiento circadiano de la EPO con dependencia del sexo e independencia de parámetros fisiológicos en jóvenes entrenados en la altura moderada

The importance of Epo as a central hormone in the process of altitude conditioning is clear given its stimulating effect on erythrocyte production. Its hormonal nature has led some researches to evaluate its circadianity with inconclusive and even contradictory reports. Objective: To analyze the circadianity of Epo in subjects who perform aerobic training at intermediate altitude (2600 masl) comparing differences between men and women. Materials and methods: We recruited residents at intermediate altitude of at least 18 months, of both sexes and who had aerobic training for at least 8 months prior to the study to measure their Epo every 4 hours for 24 hours and correlate it with some physiological and environmental variables. Results: There is circadian behavior in Epo for both men and women, with a mesor for men of 20:10 h and 16:33 h for women. As for acrophase, this occurs at 17:52 h for males and 15:50 h for females. The mean difference analysis shows a statistically significant difference between the two groups Conclusion: There is a differential circadianity between men and women in terms of their Epo levels, which is independent of physiological and environmental variables. Theme: Circadian rhythm. Subtopic: Erythropoietin.