Evidencia de asociación entre el genotipo 10/10 de DAT1 y endofenotipos del trastorno por déficit de atención/hiperactividad

J. A. Agudelo, J. M. Gálvez, D. J. Fonseca, H. E. Mateus, C. Talero-Gutiérrez, A. Velez-Van-Meerbeke

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

© 2013 Sociedad Española de Neurología.Introduction: Genetic variance of attention deficit-hyperactivity disorder (ADHD) is a strong determinant of this disorder. The 40 base pairs (bp) variable number tandem repeat (VNTR) located in the 3' untranslated region (UTR) of DAT1 gene increases the expression of the dopamine transporter. Therefore, DAT1 has been associated with susceptibility to ADHD. Objective: To determine the association between the VNTR of DAT1 and the phenotype of ADHD or its endophenotypes in a sample of children aged between 6 and 15 years from Bogotá. Subjects and methods: We selected 73 patients with ADHD and 54 controls. WISC test was applied in all subjects and executive functions were assessed. The VNTR of DAT1 was polymerase chain reaction-amplified. Data regarding population genetics and statistical analysis were obtained. Correlation and association tests between genotype and neuropsychological testing were performed. Results: The DAT1 polymorphism was not associated with ADHD (P=85). Nevertheless, the 10/10 genotype was found to be correlated with the processing speed index (P
Original languageSpanish
Pages (from-to)137 - 143
Number of pages6
JournalNeurologia
Volume30
Issue number3
DOIs
StatePublished - Apr 1 2015

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