Evaluation of OIDx Histoplasma urinary antigen EIA

Diego H Cáceres; Beatriz L. Gómez; Ángela M Tobón; Tom M Chiller; Mark D Lindsley

doi:10.1007/s11046-021-00602-9

Evaluation of OIDx Histoplasma urinary antigen EIA

Diego H Cáceres
, Beatriz L. Gómez
, Ángela M Tobón
, Tom M Chiller
, Mark D Lindsley

Research output: Contribution to Journal › Research Article › peer-review

14 Scopus citations

Abstract

A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

Translated title of the contribution	Evaluación del antígeno urinario de Histoplasma OIDx EIA
Original language	English (US)
Pages (from-to)	129–131
Journal	Mycopathologia
Volume	187
DOIs	https://doi.org/10.1007/s11046-021-00602-9
State	Published - Nov 20 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1007/s11046-021-00602-9

Cite this

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title = "Evaluation of OIDx Histoplasma urinary antigen EIA",

abstract = "A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92\%, specificity of 32\% and accuracy of 51\%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68\% of specimens tested.",

author = "C{\'a}ceres, \{Diego H\} and G{\'o}mez, \{Beatriz L.\} and Tob{\'o}n, \{{\'A}ngela M\} and Chiller, \{Tom M\} and Lindsley, \{Mark D\}",

note = "{\textcopyright} 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

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doi = "10.1007/s11046-021-00602-9",

language = "English (US)",

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T1 - Evaluation of OIDx Histoplasma urinary antigen EIA

AU - Cáceres, Diego H

AU - Gómez, Beatriz L.

AU - Tobón, Ángela M

AU - Chiller, Tom M

AU - Lindsley, Mark D

PY - 2021/11/20

Y1 - 2021/11/20

N2 - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

AB - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

U2 - 10.1007/s11046-021-00602-9

DO - 10.1007/s11046-021-00602-9

M3 - Research Article

C2 - 34802111

SN - 0301-486X

VL - 187

SP - 129

EP - 131

JO - Mycopathologia

JF - Mycopathologia