Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Diego H Cáceres; Alejandra Zuluaga; Ángela M Tabares; Tom Chiller; Ángel González; Beatriz L Gómez

doi:10.1590/S1678-9946201759076

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Diego H Cáceres, Alejandra Zuluaga, Ángela M Tabares, Tom Chiller, Ángel González, Beatriz L Gómez

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Abstract

A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

Original language	English (US)
Pages (from-to)	e76
Journal	Revista do Instituto de Medicina Tropical de Sao Paulo
Volume	59
DOIs	https://doi.org/10.1590/S1678-9946201759076
State	Published - Dec 21 2017

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title = "Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia",

abstract = "A Lateral Flow Assay to detect cryptococcal antigen (CrAg{\textregistered} LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg{\textregistered} LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS{\textregistered}) and CrAg{\textregistered} LFA was observed. CrAg{\textregistered} LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.",

author = "C{\'a}ceres, {Diego H} and Alejandra Zuluaga and Tabares, {{\'A}ngela M} and Tom Chiller and {\'A}ngel Gonz{\'a}lez and G{\'o}mez, {Beatriz L}",

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T1 - Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

AU - Cáceres, Diego H

AU - Zuluaga, Alejandra

AU - Tabares, Ángela M

AU - Chiller, Tom

AU - González, Ángel

AU - Gómez, Beatriz L

PY - 2017/12/21

Y1 - 2017/12/21

N2 - A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

AB - A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

U2 - 10.1590/S1678-9946201759076

DO - 10.1590/S1678-9946201759076

M3 - Article

C2 - 29267584

SN - 0036-4665

VL - 59

SP - e76

JO - Revista do Instituto de Medicina Tropical de Sao Paulo

JF - Revista do Instituto de Medicina Tropical de Sao Paulo

ER -

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Abstract

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