Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Diego H Cáceres, Alejandra Zuluaga, Ángela M Tabares, Tom Chiller, Ángel González, Beatriz L Gómez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

Original languageEnglish (US)
Pages (from-to)e76
JournalRevista do Instituto de Medicina Tropical de Sao Paulo
Volume59
DOIs
StatePublished - Dec 21 2017
Externally publishedYes

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