Evaluating Lanthanide-Doped Carbon Dots for Sensing Glucose and pH Within the Concentration Range of Clinical Interest

Maria J. Guluma-Escamilla, Johan S. Bolanos Prieto, Alvaro D. Orjuela-Canon, Sebastian Jaramillo-Isaza, Diana C. Rodriguez Burbano

Research output: Chapter in Book/InformConference contribution

Abstract

Monitoring glucose and pH levels is essential for tracking diabetes and preventing complications. Even though traditional sensing methods such as immunoassays, chromatog-raphy and wearables are effective, they still have limitations in the practicality, accessibility, and variability of fluid used for sensing. This research explores a different approach to developing a sensing platform for glucose and pH detection using carbon dots (CDs) doped with lanthanide ions (Gd3+ and Yb3+). Comparing fluorescence responses of three different nanoplatforms (CDs, :Gd3+$ and CDs: Gd3+/Yb3+) at various pH and glucose concentrations within the concentration range of clinical interest of these analytes in biofluids such as blood serum, saliva, and urine, allows us to identify the most effective nanoplatforms: CDs for blood serum, CDs:Gd3+ for saliva, and CDs:Gd3+/Yb3+ for urine. Using a fixed excitation wavelength of 500 nm, significant fluorescence variations were evidenced within the control and variance between them. These early results are encouraging and allow for identifying potential new applications of CDs in the biomedical field, especially in the monitoring diseases such as diabetes and pH changes.

Original languageEnglish (US)
Title of host publication2024 3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9798331532352
DOIs
StatePublished - 2024
Event3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024 - Cali, Colombia
Duration: Nov 6 2024Nov 8 2024

Publication series

Name2024 3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024

Conference

Conference3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024
Country/TerritoryColombia
CityCali
Period11/6/2411/8/24

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Bioengineering
  • Biomedical Engineering
  • Media Technology

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