TY - GEN
T1 - Evaluating Lanthanide-Doped Carbon Dots for Sensing Glucose and pH Within the Concentration Range of Clinical Interest
AU - Guluma-Escamilla, Maria J.
AU - Bolanos Prieto, Johan S.
AU - Orjuela-Canon, Alvaro D.
AU - Jaramillo-Isaza, Sebastian
AU - Rodriguez Burbano, Diana C.
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - Monitoring glucose and pH levels is essential for tracking diabetes and preventing complications. Even though traditional sensing methods such as immunoassays, chromatog-raphy and wearables are effective, they still have limitations in the practicality, accessibility, and variability of fluid used for sensing. This research explores a different approach to developing a sensing platform for glucose and pH detection using carbon dots (CDs) doped with lanthanide ions (Gd3+ and Yb3+). Comparing fluorescence responses of three different nanoplatforms (CDs, :Gd3+$ and CDs: Gd3+/Yb3+) at various pH and glucose concentrations within the concentration range of clinical interest of these analytes in biofluids such as blood serum, saliva, and urine, allows us to identify the most effective nanoplatforms: CDs for blood serum, CDs:Gd3+ for saliva, and CDs:Gd3+/Yb3+ for urine. Using a fixed excitation wavelength of 500 nm, significant fluorescence variations were evidenced within the control and variance between them. These early results are encouraging and allow for identifying potential new applications of CDs in the biomedical field, especially in the monitoring diseases such as diabetes and pH changes.
AB - Monitoring glucose and pH levels is essential for tracking diabetes and preventing complications. Even though traditional sensing methods such as immunoassays, chromatog-raphy and wearables are effective, they still have limitations in the practicality, accessibility, and variability of fluid used for sensing. This research explores a different approach to developing a sensing platform for glucose and pH detection using carbon dots (CDs) doped with lanthanide ions (Gd3+ and Yb3+). Comparing fluorescence responses of three different nanoplatforms (CDs, :Gd3+$ and CDs: Gd3+/Yb3+) at various pH and glucose concentrations within the concentration range of clinical interest of these analytes in biofluids such as blood serum, saliva, and urine, allows us to identify the most effective nanoplatforms: CDs for blood serum, CDs:Gd3+ for saliva, and CDs:Gd3+/Yb3+ for urine. Using a fixed excitation wavelength of 500 nm, significant fluorescence variations were evidenced within the control and variance between them. These early results are encouraging and allow for identifying potential new applications of CDs in the biomedical field, especially in the monitoring diseases such as diabetes and pH changes.
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U2 - 10.1109/CIIBBI63846.2024.10785007
DO - 10.1109/CIIBBI63846.2024.10785007
M3 - Conference contribution
AN - SCOPUS:85215312364
T3 - 2024 3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024
BT - 2024 3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 3rd International Congress of Biomedical Engineering and Bioengineering, CIIBBI 2024
Y2 - 6 November 2024 through 8 November 2024
ER -