Ecological interactions of sand flies, hosts, and Leishmania panamensis in an endemic area of cutaneous leishmaniasis in Colombia

Laura Posada-López, Andrés Velez-Mira, Omar Cantillo, Adriana Castillo-Castañeda, Juan David Ramírez, Eunice A.B. Galati, Fredy Galvis-Ovallos

Research output: Contribution to journalArticlepeer-review

Abstract

Background The transmission dynamics of leishmaniasis are complex. There is also a lack of information about the ecological relationships between the vector/host/parasite at a more local and specific level. The Andean region concentrates more than 50% of Colombia’s cutaneous leish-maniasis (CL) cases. The study of the ecological interactions of sand flies through the identification of blood sources has provided information on the female’s opportunistic behav-ior, feeding on various hosts. Therefore, this study aimed to determine sand flies’ ecological interactions with Leishmania parasites and their blood sources in an endemic area of CL. Results A total of 4,621 sand flies were collected, comprising 20 species, in which the most abun-dant were Nyssomyia yuilli yuilli (55.4%), Psychodopygus ayrozai (14.5%) and Ps. pana-mensis (13.4%). Sequences of 12S gene fragment were analyzed using the BLASTn search tool. Blood-meal source identification was successfully performed for 47 sand flies, detecting seven vertebrate species, human and armadillo being the most frequent. Leishmania DNA was amplified in four female pools, constituted by Ny. yuilli yuilli and Ps. ayrozai, and the identification through RFLP detected Leishmania (Viannia) panamensis in the positive pools. Conclusions The interactions between the sand fly species, local mammalian fauna and the Leishmania parasite in this active focus of CL, provide evidence of the potential role of two different species in the maintenance of the parasite transmission, important information for the understanding of the ecoepidemiology and transmission dynamics of the disease in Andean endemic areas. However its necessary further evaluations of the vector and host compe-tence in the transmission and maintenance of Leishmania spp, in these complex and diverse areas.

Original languageEnglish (US)
Article numbere0011316
JournalPLoS Neglected Tropical Diseases
Volume17
Issue number5
DOIs
StatePublished - May 2023

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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