Stent liberadores de medicamento en enfermedad coronaria prematura en jóvenes con hipercolesterolemia familiar homocigota y trasplante hepático previo

Translated title of the contribution: Drug-eluting stents in premature coronary disease in young people with homozygous familial hypercholesterolemia and prior liver transplantation

Darío Echeverri, Jaime R. Cabrales, Juan Hernando del Portillo, Dairo Rey

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Familial hypercholesterolemia is a genetic disorder characterised by very high cholesterol and low-density lipoproteins serum levels, tendon xanthomas and premature atherosclerosis. Heterozygous form is the most common, with a prevalence of approximately 1 out of 300 to 500 people worldwide, whereas the homozygous, autosomal dominant, is the rarest form, with a prevalence of 1 out of 1 million people. It is characterised by severe hypercholesterolemia leading to premature cardiovascular disease, and it often does not respond to traditional therapy due to the lack of receptors for functional LDL-c. LDL-c levels can exceed between six and ten times the normal values, in which case liver transplantation has become the treatment of choice for patients who do not respond to routine pharmacological therapies. This study presents two cases of homozygous familial hypercholesterolemia in young patients aged 14 and 15, with prior liver transplantation and severe coronary disease in major vessels (anterior descending artery and right coronary artery) who underwent successful implant of a drug-eluting stent.

Translated title of the contributionDrug-eluting stents in premature coronary disease in young people with homozygous familial hypercholesterolemia and prior liver transplantation
Original languageSpanish
Pages (from-to)351-360
Number of pages10
JournalRevista Colombiana de Cardiologia
Volume24
Issue number4
DOIs
StatePublished - Jul 1 2017

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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