Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Alexander Caicedo; Carolina Varon; Thomas Alderliesten; Petra Lemmers; Frank Van Bel; Gunnar Naulaers; Sabine Van Huffel

doi:10.1109/EMBC.2014.6944552

Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Alexander Caicedo, Carolina Varon, Thomas Alderliesten, Petra Lemmers, Frank Van Bel, Gunnar Naulaers, Sabine Van Huffel

Research output: Chapter in Book/Inform › Conference contribution

8 Scopus citations

Abstract

Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO₂) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO₂ is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.

Original language	English (US)
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4208-4211
Number of pages	4
ISBN (Electronic)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6944552
State	Published - Nov 2 2014
Externally published	Yes
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Publication series

Name	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Conference

Conference	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/Territory	United States
City	Chicago
Period	8/26/14 → 8/30/14

All Science Journal Classification (ASJC) codes

Health Informatics
Computer Science Applications
Biomedical Engineering
General Medicine

Access to Document

10.1109/EMBC.2014.6944552

Cite this

Caicedo, A., Varon, C., Alderliesten, T., Lemmers, P., Van Bel, F., Naulaers, G., & Van Huffel, S. (2014). Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 4208-4211). Article 6944552 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944552

Caicedo, Alexander ; Varon, Carolina ; Alderliesten, Thomas et al. / Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 4208-4211 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

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title = "Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging",

abstract = "Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO2) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO2 is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.",

author = "Alexander Caicedo and Carolina Varon and Thomas Alderliesten and Petra Lemmers and {Van Bel}, Frank and Gunnar Naulaers and {Van Huffel}, Sabine",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.; 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 ; Conference date: 26-08-2014 Through 30-08-2014",

year = "2014",

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doi = "10.1109/EMBC.2014.6944552",

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Caicedo, A, Varon, C, Alderliesten, T, Lemmers, P, Van Bel, F, Naulaers, G & Van Huffel, S 2014, Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6944552, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Institute of Electrical and Electronics Engineers Inc., pp. 4208-4211, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6944552

Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging. / Caicedo, Alexander; Varon, Carolina; Alderliesten, Thomas et al.
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 4208-4211 6944552 (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Inform › Conference contribution

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T1 - Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

AU - Caicedo, Alexander

AU - Varon, Carolina

AU - Alderliesten, Thomas

AU - Lemmers, Petra

AU - Van Bel, Frank

AU - Naulaers, Gunnar

AU - Van Huffel, Sabine

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO2) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO2 is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.

AB - Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO2) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO2 is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.

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ER -

Caicedo A, Varon C, Alderliesten T, Lemmers P, Van Bel F, Naulaers G et al. Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 4208-4211. 6944552. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). doi: 10.1109/EMBC.2014.6944552

Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Abstract

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