Development of Green-Yellow Fluorescent Boron-Doped Carbon Dots as a Base Structure for Future Construction of Potential Cancer Theranostic Nanoplatform

S. A. Barragan Sicua, M. D. Soto Florido, P. A. Wilches-Castellanos, A. Ondo-Méndez, D. C. Rodríguez Burbano

Research output: Chapter in Book/ReportConference contribution

Abstract

Cancer is one of the diseases with the highest mortality rate worldwide. Recent studies have shown that different types of nanoparticles, such as carbon dots (CDs), are promising candidates in applications against cancer due to their physical-chemical properties. Moreover, CDs have a high load capacity to integrate with heteroatoms or drugs through doping and functionalization. Here we report the synthesis and characterization of undoped CDs (uCDs) and boron-doped CDs (B-CDs). They were synthesized in a one-step, microwave-assisted reaction at 200 ℃, using citric acid as the carbon source, and four different amino acids were evaluated as nitrogen precursors. Additionally, boric acid was used as the boron precursor for synthesizing B-CDs, obtaining nanoparticles that exhibit green-yellow fluorescence. MTT assay showed that both, uCDs and B-CDs are biocompatible exhibiting viability rates of over 80% after 24 h in HT29, 3T3-L1, U87, and VERO cell lines. The obtained results represent an excellent opportunity to apply these developed B-CDs as cancer theranostic nanoagents and bioimaging probes. In particular, its boron content as a dopant makes them a promising alternative for boron neutron capture therapy (BCNT).

Translated title of the contributionDesarrollo de puntos de carbono verde-amarillo fluorescentes dopados con boro como estructura base para la futura construcción de una posible nanoplataforma teranóstica contra el cáncer
Original languageEnglish (US)
Title of host publication9th Latin American Congress on Biomedical Engineering and 28th Brazilian Congress on Biomedical Engineering - Proceedings of CLAIB and CBEB 2022—Volume 3
Subtitle of host publicationBiomechanics, Biomedical Devices and Assistive Technologies
EditorsJefferson Luiz Brum Marques, Cesar Ramos Rodrigues, Daniela Ota Hisayasu Suzuki, Renato García Ojeda, José Marino Neto
PublisherSpringer Science and Business Media Deutschland GmbH
Pages496-505
Number of pages10
Volume100
ISBN (Electronic)978-3-031-49407-9
ISBN (Print)978-3-031-49406-2
DOIs
StatePublished - Jan 4 2024
Event9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022 - Florianópolis, Brazil
Duration: Oct 24 2022Oct 28 2022

Publication series

NameIFMBE Proceedings
Volume100
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

Conference9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022
Country/TerritoryBrazil
CityFlorianópolis
Period10/24/2210/28/22

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Oncology

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