Decoupling the influence of systemic variables in the peripheral and cerebral haemodynamics during ECMO procedure by means of oblique and orthogonal subspace projections

A. Caicedo, I. Tachtsidis, M. D. Papademetriou, S. Van Huffel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

Extra-Corporeal Membrane Oxygenation (ECMO) is a life support system for infants and children with cardio-respiratory failure. During ECMO it is possible to have unstable cerebral haemodynamics, due to strong oscillations in the systemic variables, among other factors, which may lead to brain damage in the patients. Therefore, monitoring the coupling between cerebral haemodynamics and systemic signals might alert us of possible imminent brain damage. In this study we explore the use of orthogonal and oblique subspace projections in the decoupling of these variables, by assessing the ratio between the projections of the haemodynamic variables, onto the subspace spanned by the systemic variables, and the original signals. The coupling of these two systems may differ as different protection mechanisms protect the peripheral system and the brain. Subspace projection was able to decompose the heamodynamic variables as a sum of components related to each systemic variable, separately. As expected, stronger coupling was found between the peripheral haemodynamic and the systemic variables.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages6153-6156
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Decoupling the influence of systemic variables in the peripheral and cerebral haemodynamics during ECMO procedure by means of oblique and orthogonal subspace projections'. Together they form a unique fingerprint.

Cite this