Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6

Manuel Rojas, Yhojan Rodríguez, Diana M. Monsalve, Yovana Pacheco, Yeny Acosta-Ampudia, Mónica Rodríguez-Jimenez, Nicolás Molano-González, Rubén D. Mantilla, Carolina Ramírez-Santana, Juan Manuel Anaya

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


OBJECTIVES: Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc. METHODS: Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data. RESULTS: Interleukin-6 (IL-6) levels were associated with severity of symptoms (β=1.8395, p=0.04), and low resilience scores (β= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity. CONCLUSIONS: The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalClinical and Experimental Rheumatology
Issue number4
StatePublished - Jul 1 2019

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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