Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development

César Reyes; Rocío Rojas-Luna; Jorge Aza-Conde; Luisa Tabares; Manuel A. Patarroyo; Manuel Elkin Patarroyo

doi:10.1016/j.bbrc.2017.05.123

Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development

César Reyes, Rocío Rojas-Luna, Jorge Aza-Conde, Luisa Tabares, Manuel A. Patarroyo, Manuel Elkin Patarroyo

Research output: Contribution to journal › Research Article › peer-review

6 Scopus citations

Abstract

A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropriate immune response. Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through ¹H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory.

Original language	English (US)
Pages (from-to)	339-345
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	489
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2017.05.123 https://doi.org/10.1016/j.bbrc.2017.05.123
State	Published - Jul 29 2017

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Reyes, C., Rojas-Luna, R., Aza-Conde, J., Tabares, L., Patarroyo, M. A., & Patarroyo, M. E. (2017). Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development. Biochemical and Biophysical Research Communications, 489(3), 339-345. https://doi.org/10.1016/j.bbrc.2017.05.123, https://doi.org/10.1016/j.bbrc.2017.05.123

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abstract = "A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropriate immune response. Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through 1H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory.",

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Reyes, C, Rojas-Luna, R, Aza-Conde, J, Tabares, L, Patarroyo, MA & Patarroyo, ME 2017, 'Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development', Biochemical and Biophysical Research Communications, vol. 489, no. 3, pp. 339-345. https://doi.org/10.1016/j.bbrc.2017.05.123, https://doi.org/10.1016/j.bbrc.2017.05.123

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AU - Reyes, César

AU - Rojas-Luna, Rocío

AU - Aza-Conde, Jorge

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AU - Patarroyo, Manuel A.

AU - Patarroyo, Manuel Elkin

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AB - A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropriate immune response. Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through 1H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory.

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Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development

Abstract

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