Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development

César Reyes, Rocío Rojas-Luna, Jorge Aza-Conde, Luisa Tabares, Manuel A. Patarroyo, Manuel Elkin Patarroyo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropriate immune response. Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through 1H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume489
Issue number3
DOIs
StatePublished - Jul 29 2017

Fingerprint

Malaria Vaccines
T-Cell Antigen Receptor
Vaccines
Immunologic Memory
Macromolecular Substances
Antigens
Peptides
Antigen Presentation
Antimalarials
HLA Antigens
Immunization
Haplorhini
Amino Acids
Antibodies
Nuclear magnetic resonance
Data storage equipment
Molecules

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Reyes, César ; Rojas-Luna, Rocío ; Aza-Conde, Jorge ; Tabares, Luisa ; Patarroyo, Manuel A. ; Patarroyo, Manuel Elkin. / Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development. In: Biochemical and Biophysical Research Communications. 2017 ; Vol. 489, No. 3. pp. 339-345.
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Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development. / Reyes, César; Rojas-Luna, Rocío; Aza-Conde, Jorge; Tabares, Luisa; Patarroyo, Manuel A.; Patarroyo, Manuel Elkin.

In: Biochemical and Biophysical Research Communications, Vol. 489, No. 3, 29.07.2017, p. 339-345.

Research output: Contribution to journalArticle

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